Skip to content
Use your HSA or FSA funds

Gene

VAPB

VAMP associated protein B and C

Summary

Cytogenetic location
20q13.32
Coordinates
Chromosome 20: 58,389,229–58,451,101 (GRCh38)
Exons
6 exons across 61.9 kb
Protein
243 amino acids
Also known as
VAP-B, VAP-C, ALS8
MANE Select transcript
ENST00000475243.6NM_004738.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Amyotrophic Lateral Sclerosis (ALS)

    • Amyotrophic Lateral Sclerosis

      A neurodegenerative disorder of upper and lower motor neurons, occurring in sporadic and familial forms.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Tofersen (Qalsody, FDA 2023) for SOD1-ALS; ASO trials for C9orf72 and FUS; riluzole; edaravone; AMX0035 (sodium phenylbutyrate-taurursodiol); multidisciplinary ALS clinic care; respiratory support; genetic counseling for family members

How VAPB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where VAPB sits. VAPB and 8 genes near it on chromosome 20, from 57,920,165 to 58,920,164.Chromosome 2020q13.32p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3358 Mb58.2 Mb58.4 Mb58.6 Mb58.8 MbCIMIP1: 58,150,897–58,161,276, forward strandCIMIP1ANKRD60: 58,216,126–58,228,653, reverse strandANKRD60RAB22A: 58,309,706–58,367,507, forward strandRAB22AVAPB: 58,389,229–58,451,101, forward strandVAPBAPCDD1L: 58,457,632–58,515,399, reverse strandAPCDD1LSTX16: 58,650,262–58,679,526, forward strandSTX16STX16-NPEPL1: 58,651,434–58,715,410, forward strandSTX16-NPEPL1NPEPL1: 58,689,125–58,719,238, forward strandNPEPL1GNAS: 58,839,669–58,911,192, forward strandGNASDiagram of VAPB: 6 exons on the forward strand of chromosome 20Exon 2: 1 known disease-causing siteExon 1: 58,389,229–58,389,517, 289 basesExon 2: 58,418,211–58,418,363, 153 basesExon 3: 58,434,602–58,434,705, 104 basesExon 4: 58,438,945–58,439,025, 81 basesExon 5: 58,440,907–58,441,083, 177 basesExon 6: 58,444,077–58,451,101, 7,025 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.8 kb of the gene's 61.9 kb; 732 of those bases code for the protein.

How a genome test reads VAPB

1

position in VAPB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 61.9 kb of VAPB, introns included, not only the 7.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VAPB gene: VAMP associated protein B and C. Retrieved 17 October 2026, from https://dantelabs.com/genes/vapb

Vancouver

Dante Labs. VAPB gene: VAMP associated protein B and C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vapb

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test