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Gene

SLC1A3

solute carrier family 1 member 3

Summary

Cytogenetic location
5p13.2
Coordinates
Chromosome 5: 36,606,606–36,688,334 (GRCh38)
Exons
10 exons across 81.7 kb
Protein
542 amino acids
Inheritance
Autosomal dominant
Also known as
EAAT1, GLAST, EA6, GLAST1, GLAST-1
MANE Select transcript
ENST00000265113.9NM_004172.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Episodic Ataxias

    • Hereditary Episodic AtaxiaAutosomal dominant

      A group of dominantly inherited ataxias with attacks of imbalance, including EA1 (KCNA1), EA2 (CACNA1A) and EA6 (SLC1A3).

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Episodic ataxia type 2 often responds to acetazolamide or 4-aminopyridine, and avoiding known triggers can reduce attacks.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How SLC1A3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 5, with a bracket where SLC1A3 sits. SLC1A3 and 6 genes near it on chromosome 5, from 36,147,470 to 37,147,469.Chromosome 55p13.2p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.336.2 Mb36.4 Mb36.6 Mb36.8 Mb37 MbLMBRD2: 36,098,327–36,151,976, reverse strandLMBRD2SKP2: 36,151,989–36,196,849, forward strandSKP2NADK2: 36,191,555–36,242,279, reverse strandNADK2RANBP3L: 36,246,912–36,302,114, reverse strandRANBP3LSLC1A3: 36,606,606–36,688,334, forward strandSLC1A3NIPBL: 36,876,716–37,066,422, forward strandNIPBLCPLANE1: 37,105,973–37,249,410, reverse strandCPLANE1Diagram of SLC1A3: 10 exons on the forward strand of chromosome 5Exon 1: 36,606,606–36,606,735, 130 basesExon 2: 36,608,329–36,608,604, 276 basesExon 3: 36,629,450–36,629,587, 138 basesExon 4: 36,671,029–36,671,233, 205 basesExon 5: 36,674,049–36,674,091, 43 basesExon 6: 36,676,892–36,677,184, 293 basesExon 7: 36,679,627–36,679,860, 234 basesExon 8: 36,680,395–36,680,589, 195 basesExon 9: 36,683,864–36,683,998, 135 basesExon 10: 36,686,065–36,688,334, 2,270 bases12468105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 81.7 kb; 1,629 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC1A3 gene: solute carrier family 1 member 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc1a3

Vancouver

Dante Labs. SLC1A3 gene: solute carrier family 1 member 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc1a3

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