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Gene

PPP2R2B

protein phosphatase 2 regulatory subunit Bbeta

Summary

Cytogenetic location
5q32
Coordinates
Chromosome 5: 146,580,742–146,878,757 (GRCh38)
Exons
10 exons across 298 kb
Protein
443 amino acids
Inheritance
Autosomal dominant
Also known as
PR55-BETA, PR52B, B55beta
Previous symbols
SCA12
MANE Select transcript
ENST00000394411.9NM_181675.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)

    • Autosomal Dominant Cerebellar AtaxiaAutosomal dominant

      A group of dominantly inherited ataxias, including SCA1, SCA2, SCA3 (Machado-Joseph disease), SCA6, SCA7, SCA17, SCA27B and DRPLA, caused by repeat expansions or point variants in genes such as ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and FGF14.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Genetic counselling and presymptomatic testing for relatives, physiotherapy and symptom management; some forms, such as SCA27B, may respond to specific medication.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How PPP2R2B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 5, with a bracket where PPP2R2B sits. PPP2R2B and 5 genes near it on chromosome 5, from 146,229,750 to 147,229,749.Chromosome 55q32p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3146.4 Mb146.6 Mb146.8 Mb147 Mb147.2 MbRBM27-POU4F3: 146,203,550–146,339,251, forward strandRBM27-POU4F3RBM27: 146,203,550–146,289,462, forward strandRBM27POU4F3: 146,338,648–146,341,728, forward strandPOU4F3TCERG1: 146,447,311–146,511,963, forward strandTCERG1GPR151: 146,513,144–146,516,190, reverse strandGPR151PPP2R2B: 146,580,742–146,878,757, reverse strandPPP2R2BDiagram of PPP2R2B: 10 exons on the reverse strand of chromosome 5Exon 10: 146,580,742–146,590,226, 9,485 basesExon 9: 146,592,971–146,593,062, 92 basesExon 8: 146,600,291–146,600,460, 170 basesExon 7: 146,638,251–146,638,415, 165 basesExon 6: 146,650,547–146,650,724, 178 basesExon 5: 146,691,128–146,691,240, 113 basesExon 4: 146,697,979–146,698,144, 166 basesExon 3: 146,701,045–146,701,142, 98 basesExon 2: 146,878,002–146,878,195, 194 basesExon 1: 146,878,591–146,878,757, 167 bases10515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.8 kb of the gene's 298 kb; 1,332 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PPP2R2B gene: protein phosphatase 2 regulatory subunit Bbeta. Retrieved 17 October 2026, from https://dantelabs.com/genes/ppp2r2b

Vancouver

Dante Labs. PPP2R2B gene: protein phosphatase 2 regulatory subunit Bbeta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ppp2r2b

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