Trait
Granulomatosis
A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test11 genes linked to Granulomatosis
Changes in these genes cause rare conditions in which Granulomatosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Very often (80–99%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Very often (80–99%) | In 1 condition |
| PRTN3proteinase 3 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 1 condition |
| CCDC91coiled-coil domain containing 91 | Often (30–79%) | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Not recorded | In 1 condition |
| CYBBcytochrome b-245 beta chain | Not recorded | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Not recorded | In 1 condition |
| NCF2neutrophil cytosolic factor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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