Trait
Sinus disease
Clinical name: Sinusitis
Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction.
Summary
- Also called
- Sinus infection, Sinus inflammation
Reference genomeGRCh38hg38
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Get my Genome Test71 genes linked to Sinus disease
Changes in these genes cause rare conditions in which Sinus disease is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| NHEJ1non-homologous end joining factor 1 | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| BLNKB cell linker | Very often (80–99%) | In 1 condition |
| BTKBruton tyrosine kinase | Very often (80–99%) | In 2 conditions |
| CD79ACD79a molecule | Very often (80–99%) | In 1 condition |
| CD79BCD79b molecule | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Very often (80–99%) | In 1 condition |
| CYBBcytochrome b-245 beta chain | Very often (80–99%) | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Very often (80–99%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Very often (80–99%) | In 1 condition |
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Very often (80–99%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Very often (80–99%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Very often (80–99%) | In 1 condition |
| IGLL1immunoglobulin lambda like polypeptide 1 | Very often (80–99%) | In 1 condition |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| NCF2neutrophil cytosolic factor 2 | Very often (80–99%) | In 1 condition |
| NCF4neutrophil cytosolic factor 4 | Very often (80–99%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Very often (80–99%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Very often (80–99%) | In 1 condition |
| PRTN3proteinase 3 | Very often (80–99%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Very often (80–99%) | In 1 condition |
| SPI1Spi-1 proto-oncogene | Very often (80–99%) | In 1 condition |
| TCF3transcription factor 3 | Very often (80–99%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Very often (80–99%) | In 1 condition |
| ADAadenosine deaminase | Often (30–79%) | In 2 conditions |
| CIITAclass II major histocompatibility complex transactivator | Often (30–79%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Often (30–79%) | In 1 condition |
| IRF1interferon regulatory factor 1 | Often (30–79%) | In 1 condition |
| RFX5regulatory factor X5 | Often (30–79%) | In 1 condition |
| RFXANKregulatory factor X associated ankyrin containing protein | Often (30–79%) | In 1 condition |
| RFXAPregulatory factor X associated protein | Often (30–79%) | In 1 condition |
| RUNX2RUNX family transcription factor 2 | Often (30–79%) | In 1 condition |
| CEACAM3CEA cell adhesion molecule 3 | Sometimes (5–29%) | In 1 condition |
| CEACAM6CEA cell adhesion molecule 6 | Sometimes (5–29%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Sometimes (5–29%) | In 1 condition |
| CLCA4chloride channel accessory 4 | Sometimes (5–29%) | In 1 condition |
| CXCR4C-X-C motif chemokine receptor 4 | Sometimes (5–29%) | In 1 condition |
| DCTN4dynactin subunit 4 | Sometimes (5–29%) | In 1 condition |
Show 31 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Sometimes (5–29%) | In 1 condition |
| EDNRAendothelin receptor type A | Sometimes (5–29%) | In 1 condition |
| EFL1elongation factor like GTPase 1 | Sometimes (5–29%) | In 1 condition |
| FOXN1forkhead box N1 | Sometimes (5–29%) | In 1 condition |
| GCLCglutamate-cysteine ligase catalytic subunit | Sometimes (5–29%) | In 1 condition |
| GSTM3glutathione S-transferase mu 3 | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 1 condition |
| HMOX1heme oxygenase 1 | Sometimes (5–29%) | In 1 condition |
| IGSF3immunoglobulin superfamily member 3 | Sometimes (5–29%) | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Sometimes (5–29%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Sometimes (5–29%) | In 1 condition |
| SBDSSBDS ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| SERPINA1serpin family A member 1 | Sometimes (5–29%) | In 1 condition |
| SLC11A1solute carrier family 11 member 1 | Sometimes (5–29%) | In 1 condition |
| SLC26A9solute carrier family 26 member 9 | Sometimes (5–29%) | In 1 condition |
| SLC6A14solute carrier family 6 member 14 | Sometimes (5–29%) | In 1 condition |
| SLC9A3solute carrier family 9 member A3 | Sometimes (5–29%) | In 1 condition |
| STX1Asyntaxin 1A | Sometimes (5–29%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Sometimes (5–29%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
| ATMATM serine/threonine kinase | Not recorded | In 1 condition |
| DNAAF3dynein axonemal assembly factor 3 | Not recorded | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Not recorded | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Not recorded | In 1 condition |
| IRF8interferon regulatory factor 8 | Not recorded | In 1 condition |
| MGPmatrix Gla protein | Not recorded | In 1 condition |
| NBNnibrin | Not recorded | In 1 condition |
| NME8NME/NM23 family member 8 | Not recorded | In 1 condition |
| PNPpurine nucleoside phosphorylase | Not recorded | In 1 condition |
| PSMB4proteasome 20S subunit beta 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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