Trait

Spot on the lung

Clinical name: Pulmonary nodule

Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging.

HPO HP:0033608

Body system: Abnormality of the respiratory system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/pulmonary-nodule.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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7 genes linked to Spot on the lung

Changes in these genes cause rare conditions in which Spot on the lung is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
NCF2neutrophil cytosolic factor 2	Always	In 1 condition
CTLA4cytotoxic T-lymphocyte associated protein 4	Sometimes (5–29%)	In 1 condition
HLA-DPA1major histocompatibility complex, class II, DP alpha 1	Sometimes (5–29%)	In 1 condition
HLA-DPB1major histocompatibility complex, class II, DP beta 1	Sometimes (5–29%)	In 1 condition
PRTN3proteinase 3	Sometimes (5–29%)	In 1 condition
PTPN22protein tyrosine phosphatase non-receptor type 22	Sometimes (5–29%)	In 1 condition
STAT1signal transducer and activator of transcription 1	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal pulmonary thoracic imaging finding

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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