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Gene

ADAMTS10

ADAM metallopeptidase with thrombospondin type 1 motif 10

Summary

Cytogenetic location
19p13.2
Coordinates
Chromosome 19: 8,580,240–8,610,715 (GRCh38)
Exons
26 exons across 30.5 kb
Protein
1,103 amino acids
Also known as
ADAM-TS10
MANE Select transcript
ENST00000597188.6NM_030957.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ADAMTS10 yet. The test sequences your whole genome, so your data includes it all the same.

How ADAMTS10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where ADAMTS10 sits. ADAMTS10 and 21 genes near it on chromosome 19, from 8,095,478 to 9,095,477.Chromosome 1919p13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.438.2 Mb8.4 Mb8.6 Mb8.8 Mb9 MbFBN3: 8,065,402–8,149,693, reverse strandFBN3CERS4: 8,206,736–8,263,716, forward strandCERS4CD320: 8,302,123–8,308,379, reverse strandRPS28: 8,307,760–8,323,567, forward strandRPS28: 8,308,283–8,321,379, reverse strandNDUFA7: 8,308,593–8,321,400, reverse strandNDUFA7KANK3: 8,322,582–8,343,281, reverse strandKANK3ANGPTL4: 8,363,223–8,374,371, forward strandANGPTL4RAB11B: 8,389,981–8,405,875, forward strandRAB11BMARCHF2: 8,411,460–8,439,017, forward strandMARCHF2HNRNPM: 8,444,767–8,489,118, forward strandHNRNPMPRAM1: 8,490,056–8,502,656, reverse strandPRAM1ZNF414: 8,509,678–8,514,177, reverse strandZNF414MYO1F: 8,517,463–8,577,473, reverse strandMYO1FADAMTS10: 8,580,240–8,610,715, reverse strandADAMTS10NFILZ: 8,630,633–8,681,151, forward strandNFILZACTL9: 8,697,400–8,698,795, reverse strandACTL9OR2Z1: 8,721,634–8,732,160, forward strandOR2Z1ZNF558: 8,806,170–8,832,319, reverse strandZNF558MBD3L1: 8,832,365–8,843,340, forward strandMBD3L1MUC16: 8,848,638–9,010,438, reverse strandMUC16OR1M1: 9,087,061–9,095,669, forward strandOR1M1Diagram of ADAMTS10: 26 exons on the reverse strand of chromosome 19Exon 25: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 26: 8,580,240–8,581,002, 763 basesExon 25: 8,584,895–8,585,054, 160 basesExon 24: 8,585,132–8,585,308, 177 basesExon 23: 8,585,456–8,585,660, 205 basesExon 22: 8,586,122–8,586,251, 130 basesExon 21: 8,586,344–8,586,470, 127 basesExon 20: 8,586,558–8,586,721, 164 basesExon 19: 8,586,816–8,586,896, 81 basesExon 18: 8,589,242–8,589,365, 124 basesExon 17: 8,589,452–8,589,585, 134 basesExon 16: 8,589,889–8,589,991, 103 basesExon 15: 8,591,800–8,591,863, 64 basesExon 14: 8,591,958–8,592,103, 146 basesExon 13: 8,592,763–8,592,870, 108 basesExon 12: 8,595,762–8,595,903, 142 basesExon 11: 8,596,073–8,596,219, 147 basesExon 10: 8,596,307–8,596,412, 106 basesExon 9: 8,596,542–8,596,585, 44 basesExon 8: 8,596,987–8,597,132, 146 basesExon 7: 8,597,234–8,597,317, 84 basesExon 6: 8,600,928–8,601,145, 218 basesExon 5: 8,603,728–8,603,884, 157 basesExon 4: 8,605,012–8,605,358, 347 basesExon 3: 8,605,623–8,605,809, 187 basesExon 2: 8,608,134–8,608,248, 115 basesExon 1: 8,610,644–8,610,715, 72 bases2625201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.3 kb of the gene's 30.5 kb; 3,312 of those bases code for the protein.

How a genome test reads ADAMTS10

11

positions in ADAMTS10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 30.5 kb of ADAMTS10, introns included, not only the 4.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADAMTS10 gene: ADAM metallopeptidase with thrombospondin type 1 motif 10. Retrieved 17 October 2026, from https://dantelabs.com/genes/adamts10

Vancouver

Dante Labs. ADAMTS10 gene: ADAM metallopeptidase with thrombospondin type 1 motif 10 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/adamts10

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