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Gene

KRT83

keratin 83

Summary

Cytogenetic location
12q13.13
Coordinates
Chromosome 12: 52,314,301–52,321,398 (GRCh38)
Exons
9 exons across 7.1 kb
Protein
493 amino acids
Inheritance
Autosomal dominant
Also known as
Hb-3
Previous symbols
KRTHB3
MANE Select transcript
ENST00000293670.3NM_002282.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How KRT83 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where KRT83 sits. KRT83 and 30 genes near it on chromosome 12, from 51,817,850 to 52,817,849.Chromosome 1212q13.13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3352 Mb52.2 Mb52.4 Mb52.6 Mb52.8 MbFIGNL2: 51,817,899–51,848,729, reverse strandFIGNL2ANKRD33: 51,888,009–51,891,727, forward strandANKRD33ACVRL1: 51,906,908–51,923,361, forward strandACVRL1ACVR1B: 51,951,675–51,997,082, forward strandACVR1BTAMALIN: 52,006,941–52,015,893, forward strandTAMALINNR4A1: 52,022,832–52,059,509, forward strandNR4A1ATG101: 52,069,246–52,077,495, forward strandATG101SMIM41: 52,079,704–52,108,255, forward strandSMIM41KRT80: 52,168,996–52,192,311, reverse strandKRT80KRT7: 52,232,520–52,252,186, forward strandKRT7KRT86: 52,249,300–52,309,163, forward strandKRT86KRT81: 52,285,913–52,291,534, reverse strandKRT81KRT83: 52,314,301–52,321,398, reverse strandKRT83KRT85: 52,360,006–52,367,481, reverse strandKRT85KRT84: 52,377,812–52,385,652, reverse strandKRT84KRT82: 52,393,931–52,406,335, reverse strandKRT82KRT75: 52,424,070–52,434,380, reverse strandKRT75KRT6B: 52,446,651–52,452,154, reverse strandKRT6BKRT6C: 52,468,516–52,473,805, reverse strandKRT6CKRT6A: 52,487,176–52,493,265, reverse strandKRT6AKRT5: 52,514,575–52,520,530, reverse strandKRT5KRT71: 52,543,909–52,553,145, reverse strandKRT71KRT74: 52,565,151–52,573,843, reverse strandKRT74KRT72: 52,585,589–52,601,538, reverse strandKRT72KRT73: 52,607,570–52,618,559, reverse strandKRT73KRT2: 52,644,558–52,652,211, reverse strandKRT2KRT1: 52,674,736–52,680,407, reverse strandKRT1KRT77: 52,689,626–52,703,524, reverse strandKRT77KRT76: 52,768,155–52,777,345, reverse strandKRT76KRT3: 52,789,685–52,796,117, reverse strandKRT3KRT4: 52,806,549–52,814,116, reverse strandKRT4Diagram of KRT83: 9 exons on the reverse strand of chromosome 12Exon 7: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 9: 52,314,301–52,314,818, 518 basesExon 8: 52,315,312–52,315,343, 32 basesExon 7: 52,315,893–52,316,113, 221 basesExon 6: 52,316,468–52,316,593, 126 basesExon 5: 52,316,859–52,317,023, 165 basesExon 4: 52,317,681–52,317,776, 96 basesExon 3: 52,317,910–52,317,970, 61 basesExon 2: 52,319,156–52,319,364, 209 basesExon 1: 52,320,952–52,321,398, 447 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 7.1 kb; 1,482 of those bases code for the protein.

How a genome test reads KRT83

3

positions in KRT83 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (33%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 7.1 kb of KRT83, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT83 gene: keratin 83. Retrieved 16 October 2026, from https://dantelabs.com/genes/krt83

Vancouver

Dante Labs. KRT83 gene: keratin 83 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/krt83

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