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Gene

IDH2

isocitrate dehydrogenase (NADP(+)) 2

Summary

Cytogenetic location
15q26.1
Coordinates
Chromosome 15: 90,083,045–90,102,468 (GRCh38)
Exons
11 exons across 19.4 kb
Protein
452 amino acids
Also known as
IDH-2
MANE Select transcript
ENST00000330062.8NM_002168.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IDH2 yet. The test sequences your whole genome, so your data includes it all the same.

How IDH2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where IDH2 sits. IDH2 and 23 genes near it on chromosome 15, from 89,592,757 to 90,592,756.Chromosome 1515q26.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.389.6 Mb89.8 Mb90 Mb90.2 Mb90.4 MbTICRR: 89,575,455–89,631,056, forward strandTICRRKIF7: 89,608,789–89,663,098, reverse strandKIF7PLIN1: 89,664,365–89,679,466, reverse strandPLIN1PEX11A: 89,677,764–89,690,786, reverse strandPEX11AWDR93: 89,690,810–89,743,639, forward strandWDR93MESP1: 89,749,875–89,751,301, reverse strandMESP1MESP2: 89,760,591–89,778,754, forward strandMESP2ANPEP: 89,784,875–89,815,401, reverse strandANPEPAP3S2: 89,830,599–89,894,638, reverse strandAP3S2ARPIN-AP3S2: 89,834,308–89,912,882, reverse strandARPIN-AP3S2ARPIN: 89,895,006–89,912,966, reverse strandARPINZNF710: 89,999,180–90,082,206, forward strandZNF710IDH2: 90,083,045–90,102,468, reverse strandIDH2SEMA4B: 90,160,604–90,229,679, forward strandSEMA4BCIB1: 90,229,939–90,234,115, reverse strandCIB1GDPGP1: 90,233,471–90,245,811, forward strandGDPGP1: 90,234,200–90,265,462, forward strandTTLL13: 90,249,530–90,265,482, forward strand: 90,249,556–90,272,208, forward strandNGRN: 90,265,643–90,284,634, forward strand: 90,266,317–90,314,499, forward strandZNF774: 90,352,240–90,369,146, forward strandZNF774IQGAP1: 90,388,207–90,502,239, forward strandIQGAP1CRTC3: 90,529,881–90,645,345, forward strandCRTC3Diagram of IDH2: 11 exons on the reverse strand of chromosome 15Exon 4: 2 known disease-causing sitesExon 11: 90,083,045–90,084,353, 1,309 basesExon 10: 90,084,816–90,084,908, 93 basesExon 9: 90,085,001–90,085,098, 98 basesExon 8: 90,085,275–90,085,387, 113 basesExon 7: 90,087,112–90,087,263, 152 basesExon 6: 90,087,439–90,087,575, 137 basesExon 5: 90,088,359–90,088,502, 144 basesExon 4: 90,088,587–90,088,747, 161 basesExon 3: 90,090,479–90,090,644, 166 basesExon 2: 90,091,553–90,091,644, 92 basesExon 1: 90,102,276–90,102,468, 193 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 19.4 kb; 1,359 of those bases code for the protein.

How a genome test reads IDH2

2

positions in IDH2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 19.4 kb of IDH2, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IDH2 gene: isocitrate dehydrogenase (NADP(+)) 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/idh2

Vancouver

Dante Labs. IDH2 gene: isocitrate dehydrogenase (NADP(+)) 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/idh2

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