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Gene

PPP1R12A

protein phosphatase 1 regulatory subunit 12A

Summary

Cytogenetic location
12q21.2-q21.31
Coordinates
Chromosome 12: 79,773,568–79,935,097 (GRCh38)
Exons
25 exons across 161.5 kb
Protein
1,030 amino acids
Also known as
MBS, M130
Previous symbols
MYPT1
MANE Select transcript
ENST00000450142.7NM_002480.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PPP1R12A yet. The test sequences your whole genome, so your data includes it all the same.

How PPP1R12A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where PPP1R12A sits. PPP1R12A and 3 genes near it on chromosome 12, from 79,354,333 to 80,354,332.Chromosome 1212q21.2-q21.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3379.4 Mb79.6 Mb79.8 Mb80 Mb80.2 MbSYT1: 78,863,650–79,452,009, forward strandSYT1PAWR: 79,574,979–79,691,397, reverse strandPAWRPPP1R12A: 79,773,568–79,935,097, reverse strandPPP1R12AOTOGL: 80,099,537–80,380,880, forward strandOTOGLDiagram of PPP1R12A: 25 exons on the reverse strand of chromosome 12Exon 22: 1 known disease-causing siteExon 21: 5 known disease-causing sitesExon 19: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 25: 79,773,568–79,776,015, 2,448 basesExon 24: 79,778,550–79,778,600, 51 basesExon 23: 79,781,815–79,781,862, 48 basesExon 22: 79,786,374–79,786,478, 105 basesExon 21: 79,788,648–79,788,783, 136 basesExon 20: 79,790,467–79,790,483, 17 basesExon 19: 79,793,863–79,793,928, 66 basesExon 18: 79,795,638–79,795,759, 122 basesExon 17: 79,796,782–79,796,950, 169 basesExon 16: 79,797,195–79,797,395, 201 basesExon 15: 79,798,494–79,798,584, 91 basesExon 14: 79,805,592–79,805,768, 177 basesExon 13: 79,806,166–79,806,333, 168 basesExon 12: 79,807,226–79,807,330, 105 basesExon 11: 79,808,483–79,808,577, 95 basesExon 10: 79,809,795–79,810,010, 216 basesExon 9: 79,817,394–79,817,518, 125 basesExon 8: 79,820,774–79,820,931, 158 basesExon 7: 79,821,078–79,821,166, 89 basesExon 6: 79,822,116–79,822,190, 75 basesExon 5: 79,828,320–79,828,464, 145 basesExon 4: 79,832,332–79,832,491, 160 basesExon 3: 79,845,302–79,845,420, 119 basesExon 2: 79,872,808–79,872,938, 131 basesExon 1: 79,934,695–79,935,097, 403 bases25201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.6 kb of the gene's 161.5 kb; 3,093 of those bases code for the protein.

How a genome test reads PPP1R12A

22

positions in PPP1R12A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 161.5 kb of PPP1R12A, introns included, not only the 5.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PPP1R12A gene: protein phosphatase 1 regulatory subunit 12A. Retrieved 17 October 2026, from https://dantelabs.com/genes/ppp1r12a

Vancouver

Dante Labs. PPP1R12A gene: protein phosphatase 1 regulatory subunit 12A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ppp1r12a

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