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Gene

RNF216

ring finger protein 216

Summary

Cytogenetic location
7p22.1
Coordinates
Chromosome 7: 5,620,047–5,781,663 (GRCh38)
Exons
17 exons across 161.6 kb
Protein
923 amino acids
Also known as
TRIAD3, UBCE7IP1, ZIN
MANE Select transcript
ENST00000389902.8NM_207111.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 3 GenCC submitters rate it definitive or strong

How RNF216 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where RNF216 sits. RNF216 and 15 genes near it on chromosome 7, from 5,200,855 to 6,200,854.Chromosome 77p22.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.35.4 Mb5.6 Mb5.8 Mb6 Mb6.2 MbWIPI2: 5,190,182–5,233,855, forward strandWIPI2SLC29A4: 5,274,369–5,307,194, forward strandSLC29A4TNRC18: 5,306,790–5,425,414, reverse strandTNRC18FBXL18: 5,431,335–5,513,814, reverse strandFBXL18ACTB: 5,526,409–5,563,902, reverse strandACTBFSCN1: 5,592,806–5,606,656, forward strandFSCN1RNF216: 5,620,047–5,781,663, reverse strandRNF216OCM: 5,879,827–5,886,363, forward strandOCMCCZ1: 5,898,692–5,926,550, forward strandCCZ1RSPH10B: 5,925,544–5,970,702, reverse strandRSPH10BPMS2: 5,970,925–6,009,130, reverse strandPMS2AIMP2: 6,009,226–6,024,655, forward strandAIMP2EIF2AK1: 6,022,247–6,059,240, reverse strandEIF2AK1ANKRD61: 6,031,376–6,036,552, forward strandANKRD61USP42: 6,104,755–6,164,429, forward strandUSP42CYTH3: 6,148,751–6,272,677, reverse strandCYTH3Diagram of RNF216: 17 exons on the reverse strand of chromosome 7Exon 14: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 4: 3 known disease-causing sitesExon 17: 5,620,047–5,623,179, 3,133 basesExon 16: 5,624,056–5,624,125, 70 basesExon 15: 5,641,154–5,641,376, 223 basesExon 14: 5,652,413–5,652,510, 98 basesExon 13: 5,711,761–5,711,839, 79 basesExon 12: 5,712,715–5,712,863, 149 basesExon 11: 5,715,053–5,715,190, 138 basesExon 10: 5,716,716–5,716,766, 51 basesExon 9: 5,721,033–5,721,172, 140 basesExon 8: 5,725,324–5,725,438, 115 basesExon 7: 5,729,432–5,729,596, 165 basesExon 6: 5,730,715–5,730,817, 103 basesExon 5: 5,739,276–5,739,352, 77 basesExon 4: 5,740,973–5,741,815, 843 basesExon 3: 5,752,846–5,752,979, 134 basesExon 2: 5,761,003–5,761,138, 136 basesExon 1: 5,781,541–5,781,663, 123 bases171510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 161.6 kb; 2,772 of those bases code for the protein.

How a genome test reads RNF216

9

positions in RNF216 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (11%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 161.6 kb of RNF216, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RNF216 gene: ring finger protein 216. Retrieved 17 October 2026, from https://dantelabs.com/genes/rnf216

Vancouver

Dante Labs. RNF216 gene: ring finger protein 216 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rnf216

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