Skip to content
Use your HSA or FSA funds

Gene

TRPM7

transient receptor potential cation channel subfamily M member 7

Summary

Cytogenetic location
15q21.2
Coordinates
Chromosome 15: 50,557,158–50,686,797 (GRCh38)
Exons
39 exons across 129.6 kb
Protein
1,865 amino acids
Also known as
CHAK1, LTRPC7, TRP-PLIK
MANE Select transcript
ENST00000646667.1NM_017672.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Hypomagnesemia

    • Familial Primary Hypomagnesemia

      A group of inherited magnesium-wasting disorders caused by variants in genes such as CLDN16, CLDN19, TRPM6, CNNM2 and FXYD2; the CLDN16 and CLDN19 forms can progress to chronic kidney disease.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Magnesium supplementation can control symptoms, and some forms need kidney function and eye monitoring.

How TRPM7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 15, with a bracket where TRPM7 sits. TRPM7 and 10 genes near it on chromosome 15, from 50,121,978 to 51,121,977.Chromosome 1515q21.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.350.2 Mb50.4 Mb50.6 Mb50.8 Mb51 MbATP8B4: 49,858,238–50,182,947, reverse strandATP8B4SLC27A2: 50,182,196–50,236,450, forward strandSLC27A2HDC: 50,241,947–50,265,965, reverse strandHDCGABPB1: 50,275,389–50,355,440, reverse strandGABPB1USP8: 50,423,584–50,514,421, forward strandUSP8USP50: 50,494,018–50,546,708, reverse strandUSP50TRPM7: 50,557,158–50,686,797, reverse strandTRPM7: 50,648,802–50,686,717, reverse strandSPPL2A: 50,702,266–50,765,948, reverse strandSPPL2AAP4E1: 50,908,668–51,005,899, forward strandAP4E1TIPE3: 51,053,489–51,105,276, reverse strandTIPE3Diagram of TRPM7: 39 exons on the reverse strand of chromosome 15Exon 39: 50,557,158–50,561,808, 4,651 basesExon 38: 50,569,887–50,569,993, 107 basesExon 37: 50,570,104–50,570,155, 52 basesExon 36: 50,574,274–50,574,479, 206 basesExon 35: 50,574,637–50,574,719, 83 basesExon 34: 50,574,852–50,575,135, 284 basesExon 33: 50,575,724–50,575,789, 66 basesExon 32: 50,575,869–50,575,919, 51 basesExon 31: 50,578,639–50,578,664, 26 basesExon 30: 50,580,874–50,580,908, 35 basesExon 29: 50,583,089–50,583,159, 71 basesExon 28: 50,586,392–50,586,488, 97 basesExon 27: 50,589,592–50,589,656, 65 basesExon 26: 50,591,911–50,592,626, 716 basesExon 25: 50,593,617–50,593,749, 133 basesExon 24: 50,594,429–50,594,613, 185 basesExon 23: 50,596,255–50,596,381, 127 basesExon 22: 50,599,122–50,599,296, 175 basesExon 21: 50,604,866–50,605,144, 279 basesExon 20: 50,607,200–50,607,328, 129 basesExon 19: 50,609,581–50,609,724, 144 basesExon 18: 50,609,806–50,609,961, 156 basesExon 17: 50,611,093–50,611,321, 229 basesExon 16: 50,612,549–50,612,829, 281 basesExon 15: 50,613,707–50,613,841, 135 basesExon 14: 50,614,123–50,614,263, 141 basesExon 13: 50,619,745–50,619,798, 54 basesExon 12: 50,624,166–50,624,300, 135 basesExon 11: 50,628,149–50,628,249, 101 basesExon 10: 50,631,417–50,631,489, 73 basesExon 9: 50,632,869–50,632,992, 124 basesExon 8: 50,634,382–50,634,556, 175 basesExon 7: 50,637,422–50,637,593, 172 basesExon 6: 50,639,424–50,639,548, 125 basesExon 5: 50,643,340–50,643,553, 214 basesExon 4: 50,648,687–50,648,885, 199 basesExon 3: 50,657,781–50,657,819, 39 basesExon 2: 50,662,967–50,663,046, 80 basesExon 1: 50,686,531–50,686,797, 267 bases39353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.4 kb of the gene's 129.6 kb; 5,598 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRPM7 gene: transient receptor potential cation channel subfamily M member 7. Retrieved 17 October 2026, from https://dantelabs.com/genes/trpm7

Vancouver

Dante Labs. TRPM7 gene: transient receptor potential cation channel subfamily M member 7 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/trpm7

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test