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Gene

GPRC5B

G protein-coupled receptor class C group 5 member B

Summary

Cytogenetic location
16p12.3
Coordinates
Chromosome 16: 19,856,691–19,884,848 (GRCh38)
Exons
4 exons across 28.2 kb
Protein
403 amino acids
Also known as
RAIG-2
MANE Select transcript
ENST00000300571.7NM_016235.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Megalencephalic Leukoencephalopathy with Subcortical Cysts

    • Megalencephalic leukoencephalopathy with subcortical cysts (MLC1, HEPACAM, GPRC5B)

      Causes an enlarged head from infancy with slowly progressive problems with balance, spasticity and sometimes seizures; some HEPACAM forms improve over time (remitting MLC).

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis explains the brain imaging findings, guides seizure and supportive care and clarifies risk for relatives.

Broader groupings

  • Other Inherited Leukodystrophies

    • Leukodystrophy (other and unspecified types)

      One of 80 genes linked to it

      Inherited conditions that damage or prevent the normal formation of myelin, the white matter of the brain and spinal cord. Different types follow autosomal recessive, autosomal dominant or X-linked inheritance depending on the gene involved.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing the specific genetic cause can end a diagnostic search, guide supportive care and surveillance, show whether a specific treatment exists, and allow testing of relatives.

How GPRC5B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 16, with a bracket where GPRC5B sits. GPRC5B and 10 genes near it on chromosome 16, from 19,370,770 to 20,370,769.Chromosome 1616p12.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.319.4 Mb19.6 Mb19.8 Mb20 Mb20.2 MbTMC5: 19,410,428–19,499,117, forward strandTMC5GDE1: 19,501,681–19,522,132, reverse strandGDE1CCP110: 19,523,808–19,553,408, forward strandCCP110VPS35L: 19,555,240–19,706,793, forward strandVPS35LKNOP1: 19,657,344–19,718,751, reverse strandKNOP1IQCK: 19,716,456–19,858,467, forward strandIQCKGPRC5B: 19,856,691–19,884,848, reverse strandGPRC5BGPR139: 20,028,239–20,073,890, reverse strandGPR139GP2: 20,309,574–20,328,412, reverse strandGP2UMOD: 20,331,489–20,356,402, reverse strandUMODPDILT: 20,359,175–20,404,737, reverse strandPDILTDiagram of GPRC5B: 4 exons on the reverse strand of chromosome 16Exon 4: 19,856,691–19,860,544, 3,854 basesExon 3: 19,861,837–19,861,973, 137 basesExon 2: 19,871,816–19,872,846, 1,031 basesExon 1: 19,884,727–19,884,848, 122 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 28.2 kb; 1,212 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPRC5B gene: G protein-coupled receptor class C group 5 member B. Retrieved 16 October 2026, from https://dantelabs.com/genes/gprc5b

Vancouver

Dante Labs. GPRC5B gene: G protein-coupled receptor class C group 5 member B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gprc5b

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