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Gene

PLAU

plasminogen activator, urokinase

Summary

Cytogenetic location
10q22.2
Coordinates
Chromosome 10: 73,911,132–73,917,494 (GRCh38)
Exons
11 exons across 6.4 kb
Protein
431 amino acids
Inheritance
Autosomal dominant
Also known as
URK, UPA
MANE Select transcript
ENST00000372764.4NM_002658.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Inherited Fibrinolytic Disorders

    • Quebec Platelet DisorderAutosomal dominant

      A dominant condition in which platelets contain too much urokinase plasminogen activator, so clots break down too quickly, causing delayed bleeding after injury or surgery.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Bleeding responds to tranexamic acid but not to platelet transfusion.

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How PLAU is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 10, with a bracket where PLAU sits. PLAU and 17 genes near it on chromosome 10, from 73,414,313 to 74,414,312.Chromosome 1010q22.2p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.373.6 Mb73.8 Mb74 Mb74.2 Mb74.4 MbANXA7: 73,365,027–73,414,731, reverse strandANXA7MSS51: 73,423,579–73,433,567, reverse strandMSS51PPP3CB: 73,436,418–73,496,034, reverse strandPPP3CBUSP54: 73,497,538–73,626,117, reverse strandUSP54MYOZ1: 73,631,556–73,642,103, reverse strandMYOZ1SYNPO2L: 73,644,881–73,663,803, reverse strandSYNPO2LAGAP5: 73,674,276–73,698,109, reverse strandAGAP5SEC24C: 73,744,348–73,772,173, forward strandSEC24CPOFUT4: 73,772,271–73,780,251, forward strandCHCHD1: 73,782,039–73,783,652, forward strandZSWIM8: 73,785,549–73,801,797, forward strandZSWIM8: 73,796,514–73,811,651, reverse strandNDST2: 73,801,740–73,811,963, reverse strandNDST2CAMK2G: 73,812,501–73,874,641, reverse strandCAMK2GPLAU: 73,911,132–73,917,494, forward strandPLAUVCL: 73,995,193–74,123,073, forward strandVCLAP3M1: 74,120,118–74,151,055, reverse strandAP3M1ADK: 74,151,185–74,709,963, forward strandADKDiagram of PLAU: 11 exons on the forward strand of chromosome 10Exon 1: 73,911,132–73,911,218, 87 basesExon 2: 73,911,525–73,911,612, 88 basesExon 3: 73,912,041–73,912,068, 28 basesExon 4: 73,912,215–73,912,322, 108 basesExon 5: 73,912,924–73,913,098, 175 basesExon 6: 73,913,290–73,913,381, 92 basesExon 7: 73,913,539–73,913,758, 220 basesExon 8: 73,913,980–73,914,128, 149 basesExon 9: 73,914,776–73,914,916, 141 basesExon 10: 73,915,251–73,915,399, 149 basesExon 11: 73,916,389–73,917,494, 1,106 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 6.4 kb; 1,296 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLAU gene: plasminogen activator, urokinase. Retrieved 17 October 2026, from https://dantelabs.com/genes/plau

Vancouver

Dante Labs. PLAU gene: plasminogen activator, urokinase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/plau

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