Skip to content
Use your HSA or FSA funds

Gene

VPS35

VPS35 retromer complex component

Summary

Cytogenetic location
16q11.2
Coordinates
Chromosome 16: 46,656,132–46,689,178 (GRCh38)
Exons
17 exons across 33 kb
Protein
796 amino acids
Also known as
FLJ10752, MEM3, PARK17
MANE Select transcript
ENST00000299138.12NM_018206.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How VPS35 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where VPS35 sits. VPS35 and 8 genes near it on chromosome 16, from 46,172,655 to 47,172,654.Chromosome 1616q11.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.346.2 Mb46.4 Mb46.6 Mb46.8 Mb47 MbSHCBP1: 46,578,565–46,621,404, reverse strandSHCBP1VPS35: 46,656,132–46,689,178, reverse strandVPS35ORC6: 46,689,301–46,698,399, forward strandORC6MYLK3: 46,701,568–46,790,407, reverse strandMYLK3HDIP1: 46,796,603–46,831,476, reverse strandHDIP1GPT2: 46,882,857–46,931,299, forward strandGPT2DNAJA2: 46,955,362–46,973,709, reverse strandDNAJA2NETO2: 47,077,703–47,144,028, reverse strandNETO2ITFG1: 47,154,387–47,464,149, reverse strandITFG1Diagram of VPS35: 17 exons on the reverse strand of chromosome 16Exon 17: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 17: 46,656,132–46,660,651, 4,520 basesExon 16: 46,661,718–46,661,861, 144 basesExon 15: 46,662,243–46,662,482, 240 basesExon 14: 46,662,983–46,663,162, 180 basesExon 13: 46,668,930–46,669,052, 123 basesExon 12: 46,671,705–46,671,860, 156 basesExon 11: 46,672,265–46,672,472, 208 basesExon 10: 46,674,314–46,674,462, 149 basesExon 9: 46,674,564–46,674,660, 97 basesExon 8: 46,676,583–46,676,692, 110 basesExon 7: 46,677,315–46,677,398, 84 basesExon 6: 46,678,943–46,679,156, 214 basesExon 5: 46,680,671–46,680,853, 183 basesExon 4: 46,681,377–46,681,500, 124 basesExon 3: 46,682,079–46,682,175, 97 basesExon 2: 46,683,508–46,683,606, 99 basesExon 1: 46,689,131–46,689,178, 48 bases1716141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 33 kb; 2,391 of those bases code for the protein.

How a genome test reads VPS35

3

positions in VPS35 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 33 kb of VPS35, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VPS35 gene: VPS35 retromer complex component. Retrieved 16 October 2026, from https://dantelabs.com/genes/vps35

Vancouver

Dante Labs. VPS35 gene: VPS35 retromer complex component [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/vps35

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test