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Gene

PRKN

parkin RBR E3 ubiquitin protein ligase

Summary

Cytogenetic location
6q26
Coordinates
Chromosome 6: 161,347,417–162,727,766 (GRCh38)
Exons
12 exons across 1,380.4 kb
Protein
465 amino acids
Also known as
PDJ, AR-JP, parkin
Previous symbols
PARK2
MANE Select transcript
ENST00000366898.6NM_004562.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How PRKN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where PRKN sits. PRKN and 10 genes near it on chromosome 6, from 159,967,067 to 164,108,116.Chromosome 66q26p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27160 Mb160.5 Mb161 Mb161.5 Mb162 Mb162.5 Mb163 Mb163.5 Mb164 MbIGF2R: 159,969,033–160,113,507, forward strandIGF2RSLC22A1: 160,121,372–160,160,590, forward strandSLC22A1SLC22A2: 160,171,061–160,277,638, reverse strandSLC22A2SLC22A3: 160,348,316–160,455,027, forward strandSLC22A3LPA: 160,531,482–160,664,276, reverse strandLPAPLG: 160,702,105–160,754,469, forward strandPLGMAP3K4: 160,991,344–161,117,385, forward strandMAP3K4AGPAT4: 161,129,967–161,274,693, reverse strandAGPAT4PRKN: 161,347,417–162,727,766, reverse strandPRKNPACRG: 162,727,095–163,315,535, forward strandPACRGQKI: 163,414,000–163,578,827, forward strandQKIDiagram of PRKN: 12 exons on the reverse strand of chromosome 6Exon 12: 4 known disease-causing sitesExon 11: 1 known disease-causing siteExon 9: 3 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 12: 161,347,417–161,350,211, 2,795 basesExon 11: 161,360,088–161,360,205, 118 basesExon 10: 161,386,794–161,386,877, 84 basesExon 9: 161,548,854–161,549,003, 150 basesExon 8: 161,569,355–161,569,416, 62 basesExon 7: 161,785,772–161,785,908, 137 basesExon 6: 161,973,302–161,973,417, 116 basesExon 5: 162,054,091–162,054,174, 84 basesExon 4: 162,201,131–162,201,252, 122 basesExon 3: 162,262,525–162,262,765, 241 basesExon 2: 162,443,310–162,443,473, 164 basesExon 1: 162,727,662–162,727,766, 105 bases1210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 1,380.4 kb; 1,398 of those bases code for the protein.

How a genome test reads PRKN

32

positions in PRKN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1,380.4 kb of PRKN, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRKN gene: parkin RBR E3 ubiquitin protein ligase. Retrieved 17 October 2026, from https://dantelabs.com/genes/prkn

Vancouver

Dante Labs. PRKN gene: parkin RBR E3 ubiquitin protein ligase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/prkn

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