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Gene

PDE10A

phosphodiesterase 10A

Summary

Cytogenetic location
6q27
Coordinates
Chromosome 6: 165,327,289–165,663,241 (GRCh38)
Exons
22 exons across 336 kb
Protein
1,055 amino acids
MANE Select transcript
ENST00000539869.4NM_001385079.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dystonia, Myotonia, Paroxysmal Dyskinesia

    • Inherited Dystonia

      Umbrella term covering inherited dystonias, including DYT-TOR1A early-onset generalized dystonia, DYT-THAP1, myoclonus-dystonia (SGCE) and KMT2B-related dystonia.

      • 3 GenCC submitters rate it definitive or strong

How PDE10A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where PDE10A sits. PDE10A and 1 gene near it on chromosome 6, from 164,991,336 to 165,999,194.Chromosome 66q27p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27165 Mb165.2 Mb165.4 Mb165.6 Mb165.8 MbC6orf118: 165,279,458–165,309,630, reverse strandC6orf118PDE10A: 165,327,289–165,663,241, reverse strandPDE10ADiagram of PDE10A: 22 exons on the reverse strand of chromosome 6Exon 16: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 22: 165,327,289–165,333,127, 5,839 basesExon 21: 165,336,123–165,336,211, 89 basesExon 20: 165,339,278–165,339,358, 81 basesExon 19: 165,343,391–165,343,502, 112 basesExon 18: 165,379,194–165,379,366, 173 basesExon 17: 165,388,298–165,388,453, 156 basesExon 16: 165,392,646–165,392,796, 151 basesExon 15: 165,395,181–165,395,264, 84 basesExon 14: 165,396,317–165,396,459, 143 basesExon 13: 165,413,501–165,413,687, 187 basesExon 12: 165,416,189–165,416,281, 93 basesExon 11: 165,418,635–165,418,777, 143 basesExon 10: 165,428,658–165,428,709, 52 basesExon 9: 165,430,287–165,430,345, 59 basesExon 8: 165,431,422–165,431,472, 51 basesExon 7: 165,432,974–165,433,129, 156 basesExon 6: 165,435,237–165,435,377, 141 basesExon 5: 165,448,928–165,448,977, 50 basesExon 4: 165,450,242–165,450,362, 121 basesExon 3: 165,482,315–165,482,343, 29 basesExon 2: 165,543,440–165,543,568, 129 basesExon 1: 165,661,947–165,663,241, 1,295 bases22201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.3 kb of the gene's 336 kb; 3,168 of those bases code for the protein.

How a genome test reads PDE10A

8

positions in PDE10A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 336 kb of PDE10A, introns included, not only the 9.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PDE10A gene: phosphodiesterase 10A. Retrieved 16 October 2026, from https://dantelabs.com/genes/pde10a

Vancouver

Dante Labs. PDE10A gene: phosphodiesterase 10A [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pde10a

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