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Gene

LRRK2

leucine rich repeat kinase 2

Summary

Cytogenetic location
12q12
Coordinates
Chromosome 12: 40,224,997–40,369,285 (GRCh38)
Exons
51 exons across 144.3 kb
Protein
2,527 amino acids
Also known as
ROCO2, DKFZp434H2111, FLJ45829, RIPK7
Previous symbols
PARK8
MANE Select transcript
ENST00000298910.12NM_198578.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How LRRK2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where LRRK2 sits. LRRK2 and 4 genes near it on chromosome 12, from 39,797,141 to 40,797,140.Chromosome 1212q12p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3339.8 Mb40 Mb40.2 Mb40.4 Mb40.6 MbREDIC1: 39,626,167–39,908,300, forward strandREDIC1SLC2A13: 39,755,025–40,106,094, reverse strandSLC2A13LRRK2: 40,224,997–40,369,285, forward strandLRRK2MUC19: 40,393,395–40,570,832, forward strandMUC19CNTN1: 40,692,431–41,073,454, forward strandCNTN1Diagram of LRRK2: 51 exons on the forward strand of chromosome 12Exon 31: 2 known disease-causing sitesExon 41: 2 known disease-causing sitesExon 1: 40,224,997–40,225,282, 286 basesExon 2: 40,225,555–40,225,640, 86 basesExon 3: 40,232,274–40,232,383, 110 basesExon 4: 40,235,626–40,235,714, 89 basesExon 5: 40,237,969–40,238,103, 135 basesExon 6: 40,240,483–40,240,617, 135 basesExon 7: 40,243,550–40,243,681, 132 basesExon 8: 40,249,826–40,249,945, 120 basesExon 9: 40,251,232–40,251,374, 143 basesExon 10: 40,251,465–40,251,544, 80 basesExon 11: 40,252,910–40,253,016, 107 basesExon 12: 40,257,248–40,257,377, 130 basesExon 13: 40,259,480–40,259,604, 125 basesExon 14: 40,263,789–40,263,901, 113 basesExon 15: 40,274,583–40,274,727, 145 basesExon 16: 40,274,854–40,274,993, 140 basesExon 17: 40,277,888–40,278,016, 129 basesExon 18: 40,278,091–40,278,261, 171 basesExon 19: 40,283,875–40,284,133, 259 basesExon 20: 40,287,351–40,287,539, 189 basesExon 21: 40,293,545–40,293,663, 119 basesExon 22: 40,294,845–40,294,914, 70 basesExon 23: 40,295,427–40,295,644, 218 basesExon 24: 40,298,243–40,298,493, 251 basesExon 25: 40,299,109–40,299,257, 149 basesExon 26: 40,302,789–40,302,882, 94 basesExon 27: 40,303,948–40,304,134, 187 basesExon 28: 40,305,785–40,305,966, 182 basesExon 29: 40,308,467–40,308,696, 230 basesExon 30: 40,309,106–40,309,233, 128 basesExon 31: 40,310,431–40,310,649, 219 basesExon 32: 40,313,972–40,314,173, 202 basesExon 33: 40,315,212–40,315,300, 89 basesExon 34: 40,319,988–40,320,175, 188 basesExon 35: 40,321,034–40,321,188, 155 basesExon 36: 40,322,035–40,322,181, 147 basesExon 37: 40,322,319–40,322,510, 192 basesExon 38: 40,323,160–40,323,306, 147 basesExon 39: 40,328,360–40,328,460, 101 basesExon 40: 40,334,967–40,335,157, 191 basesExon 41: 40,340,294–40,340,454, 161 basesExon 42: 40,346,753–40,346,923, 171 basesExon 43: 40,348,409–40,348,509, 101 basesExon 44: 40,351,539–40,351,733, 195 basesExon 45: 40,354,299–40,354,492, 194 basesExon 46: 40,356,115–40,356,187, 73 basesExon 47: 40,359,260–40,359,444, 185 basesExon 48: 40,363,402–40,363,554, 153 basesExon 49: 40,364,842–40,365,050, 209 basesExon 50: 40,367,006–40,367,077, 72 basesExon 51: 40,367,644–40,369,285, 1,642 bases12040515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.2 kb of the gene's 144.3 kb; 7,584 of those bases code for the protein.

How a genome test reads LRRK2

4

positions in LRRK2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 144.3 kb of LRRK2, introns included, not only the 9.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LRRK2 gene: leucine rich repeat kinase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/lrrk2

Vancouver

Dante Labs. LRRK2 gene: leucine rich repeat kinase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lrrk2

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