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Gene

ZFYVE26

zinc finger FYVE-type containing 26

Summary

Cytogenetic location
14q24.1
Coordinates
Chromosome 14: 67,746,522–67,816,590 (GRCh38)
Exons
42 exons across 70.1 kb
Protein
2,539 amino acids
Also known as
KIAA0321
Previous symbols
SPG15
MANE Select transcript
ENST00000347230.9NM_015346.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hereditary Spastic Paraplegia

    • Hereditary Spastic Paraplegia 15Autosomal recessive

      Autosomal recessive spastic paraplegia type 15 is a complex form of hereditary spastic paraplegia characterized by a childhood to adulthood onset of slowly progressive lower limb spasticity (resulting in gait disturbance, extensor plantar responses and decreased vibration sense) associated with mild intellectual disability, mild cerebellar ataxia, peripheral neuropathy (with distal upper limb amyotrophy) and retinal degeneration. Thin corpus callosum is a common imaging finding.

      • 4 GenCC submitters rate it definitive or strong
    • Hereditary Spastic Paraplegia (All Types)

      One of 66 genes linked to it

      Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

      • 4 GenCC submitters rate it definitive or strong

How ZFYVE26 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where ZFYVE26 sits. ZFYVE26 and 13 genes near it on chromosome 14, from 67,281,556 to 68,281,555.Chromosome 1414q24.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3367.4 Mb67.6 Mb67.8 Mb68 Mb68.2 MbPALS1: 67,240,713–67,336,061, forward strandPALS1ATP6V1D: 67,294,371–67,360,265, reverse strandATP6V1DEIF2S1: 67,359,993–67,394,395, forward strandEIF2S1PLEK2: 67,385,652–67,412,236, reverse strandPLEK2TMEM229B: 67,447,084–67,533,878, reverse strandTMEM229BPLEKHH1: 67,533,063–67,589,725, forward strandPLEKHH1PIGH: 67,581,955–67,600,316, reverse strandPIGHARG2: 67,619,857–67,667,328, forward strandARG2VTI1B: 67,635,307–67,674,920, reverse strandVTI1B: 67,659,820–67,690,367, reverse strandRDH11: 67,676,792–67,695,793, reverse strandRDH11RDH12: 67,701,886–67,734,451, forward strandRDH12ZFYVE26: 67,746,522–67,816,590, reverse strandZFYVE26RAD51B: 67,819,741–68,730,218, forward strandRAD51BDiagram of ZFYVE26: 42 exons on the reverse strand of chromosome 14Exon 40: 3 known disease-causing sitesExon 39: 2 known disease-causing sitesExon 38: 4 known disease-causing sitesExon 37: 4 known disease-causing sitesExon 36: 12 known disease-causing sitesExon 35: 7 known disease-causing sitesExon 34: 8 known disease-causing sitesExon 33: 5 known disease-causing sitesExon 32: 8 known disease-causing sitesExon 31: 5 known disease-causing sitesExon 29: 6 known disease-causing sitesExon 28: 5 known disease-causing sitesExon 27: 2 known disease-causing sitesExon 26: 8 known disease-causing sitesExon 25: 5 known disease-causing sitesExon 24: 7 known disease-causing sitesExon 23: 5 known disease-causing sitesExon 22: 8 known disease-causing sitesExon 21: 32 known disease-causing sitesExon 20: 1 known disease-causing siteExon 19: 9 known disease-causing sitesExon 18: 4 known disease-causing sitesExon 17: 7 known disease-causing sitesExon 16: 6 known disease-causing sitesExon 15: 7 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 4 known disease-causing sitesExon 11: 32 known disease-causing sitesExon 10: 8 known disease-causing sitesExon 9: 6 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 7: 9 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 5: 18 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 42: 67,746,522–67,748,639, 2,118 basesExon 41: 67,751,052–67,751,096, 45 basesExon 40: 67,752,344–67,752,526, 183 basesExon 39: 67,753,707–67,753,766, 60 basesExon 38: 67,754,071–67,754,212, 142 basesExon 37: 67,755,051–67,755,250, 200 basesExon 36: 67,755,948–67,756,145, 198 basesExon 35: 67,761,366–67,761,584, 219 basesExon 34: 67,762,203–67,762,412, 210 basesExon 33: 67,762,672–67,762,819, 148 basesExon 32: 67,766,227–67,766,447, 221 basesExon 31: 67,767,704–67,767,840, 137 basesExon 30: 67,768,517–67,768,548, 32 basesExon 29: 67,769,594–67,769,730, 137 basesExon 28: 67,772,047–67,772,210, 164 basesExon 27: 67,775,016–67,775,114, 99 basesExon 26: 67,775,860–67,776,106, 247 basesExon 25: 67,777,559–67,777,735, 177 basesExon 24: 67,778,126–67,778,248, 123 basesExon 23: 67,780,241–67,780,345, 105 basesExon 22: 67,781,333–67,781,529, 197 basesExon 21: 67,782,780–67,783,525, 746 basesExon 20: 67,784,334–67,784,436, 103 basesExon 19: 67,785,059–67,785,277, 219 basesExon 18: 67,785,858–67,786,022, 165 basesExon 17: 67,786,114–67,786,233, 120 basesExon 16: 67,789,335–67,789,598, 264 basesExon 15: 67,790,572–67,790,773, 202 basesExon 14: 67,793,608–67,793,759, 152 basesExon 13: 67,794,171–67,794,239, 69 basesExon 12: 67,797,672–67,797,755, 84 basesExon 11: 67,798,014–67,798,622, 609 basesExon 10: 67,802,079–67,802,282, 204 basesExon 9: 67,804,101–67,804,264, 164 basesExon 8: 67,805,217–67,805,305, 89 basesExon 7: 67,805,454–67,805,618, 165 basesExon 6: 67,806,545–67,806,675, 131 basesExon 5: 67,807,398–67,807,920, 523 basesExon 4: 67,809,200–67,809,289, 90 basesExon 3: 67,813,986–67,814,064, 79 basesExon 2: 67,815,770–67,816,046, 277 basesExon 1: 67,816,534–67,816,590, 57 bases4240353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.7 kb of the gene's 70.1 kb; 7,620 of those bases code for the protein.

Sequencing ZFYVE26

291

positions in ZFYVE26 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 70.1 kb of ZFYVE26, introns included, not only the 9.7 kb of exons.

Genes linked to the same conditions

Traits linked to ZFYVE26

The Human Phenotype Ontology lists these as features of the rare conditions ZFYVE26 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). ZFYVE26 gene: zinc finger FYVE-type containing 26. Retrieved 17 October 2026, from https://dantelabs.com/genes/zfyve26

Vancouver

Dante Labs. ZFYVE26 gene: zinc finger FYVE-type containing 26 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/zfyve26

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