Traits

Traits linked to TANGO2

transport and golgi organization 2 homolog

The Human Phenotype Ontology links 88 traits to TANGO2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	나타나는 빈도
Absent speech development	항상
Ataxia	항상
Babinski sign	항상
Brisk reflexes	항상
Clonus	항상
Coma	항상
Difficulty articulating speech	항상
Global developmental delay	항상
Intellectual disability	항상
Loss of developmental milestones	항상
Motor delay	항상
Repeated seizures without recovery between them	항상
Abnormality of extrapyramidal motor function	자주 (30–79%)
Degeneration of cerebrum	자주 (30–79%)
Delayed ability to walk	자주 (30–79%)
Delayed speech and language development	자주 (30–79%)
Epilepsy	자주 (30–79%)
Generalized brain degeneration	자주 (30–79%)
Incoordination	자주 (30–79%)
Involuntary movements	자주 (30–79%)
Moderate global developmental delay	자주 (30–79%)
Dystonia	가끔 (5–29%)
Focal impaired awareness seizure	가끔 (5–29%)
Generalized myoclonic seizure	가끔 (5–29%)
Generalized tonic seizure	가끔 (5–29%)
Grand mal seizures	가끔 (5–29%)
Increased reflexes	가끔 (5–29%)
Infantile spasms	가끔 (5–29%)
Mild global developmental delay	가끔 (5–29%)
Multifocal seizures	가끔 (5–29%)
Severe global developmental delay	가끔 (5–29%)
Abnormal gait	기록되지 않음
Hyperactive deep tendon reflexes	기록되지 않음
Inability to coordinate movements when walking	기록되지 않음
Ongoing loss of nerve cells	기록되지 않음

Trait	나타나는 빈도
Elevated blood creatine phosphokinase	항상
Elevated circulating alanine aminotransferase concentration	항상
Elevated circulating aldolase concentration	항상
Elevated circulating aspartate aminotransferase concentration	항상
Metabolic acidosis	항상
Myoglobinuria	항상
Elevated circulating tetradecenoylcarnitine concentration	매우 자주 (80–99%)
High blood ammonia levels	매우 자주 (80–99%)
Higher than normal levels of lactate in blood	매우 자주 (80–99%)
Increased lactate in body	매우 자주 (80–99%)
Ketonuria	매우 자주 (80–99%)
High liver enzymes	자주 (30–79%)
Low blood sugar	자주 (30–79%)
Elevated circulating fatty acylcarnitine concentration	가끔 (5–29%)
Hypoglycemic seizures	가끔 (5–29%)

Trait	나타나는 빈도
Abnormal EKG	매우 자주 (80–99%)
Abnormal heart rate	자주 (30–79%)
Prolonged QT interval	자주 (30–79%)
Prolonged QTc interval	자주 (30–79%)
Ventricular tachycardia	자주 (30–79%)
Enlarged and thickened heart muscle	가끔 (5–29%)
Extra heart beat	가끔 (5–29%)
Slow heartbeats	가끔 (5–29%)
Stroke	가끔 (5–29%)
Torsade de pointes	가끔 (5–29%)
Heart stops beating	기록되지 않음
Ventricular fibrillation	기록되지 않음

Trait	나타나는 빈도
Lower limb spasticity	항상
Breakdown of skeletal muscle	매우 자주 (80–99%)
EMG: myopathic abnormalities	매우 자주 (80–99%)
Acute rhabdomyolysis	자주 (30–79%)
Spastic diplegia	가끔 (5–29%)
Spastic tetraplegia	가끔 (5–29%)
Spasticity and rigidity of muscles	가끔 (5–29%)
Generalized decreased muscle tone	기록되지 않음
Muscle weakness	기록되지 않음

Trait	나타나는 빈도
Cerebral visual impairment	가끔 (5–29%)
Involuntary, rapid, rhythmic eye movements	가끔 (5–29%)
Lazy eye	가끔 (5–29%)
Optic atrophy	가끔 (5–29%)
Supranuclear gaze palsy	가끔 (5–29%)

Trait	나타나는 빈도
Feeding difficulties in infancy	자주 (30–79%)
Gastrointestinal dysmotility	자주 (30–79%)
Poor swallowing	가끔 (5–29%)
Oral-pharyngeal dysphagia	기록되지 않음

Trait	나타나는 빈도
Compensated hypothyroidism	자주 (30–79%)
Premature breast development	가끔 (5–29%)
Premature pubic hair growth	가끔 (5–29%)
Underactive thyroid	기록되지 않음

Trait	나타나는 빈도
Sensorineural hearing impairment	가끔 (5–29%)

Human Phenotype Ontology가 기록한, 해당 유전자와 관련된 질환을 가진 사람들 가운데 이 특징이 나타나는 빈도입니다. 이 페이지는 특징과 그 바탕이 되는 연구를 설명하며, 진단이 아닙니다. 증상에 대해서는 의사나 유전 상담사에게 문의하시기 바랍니다.

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TANGO2 and how often each is seen. Find out more at hpo.jax.org.

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