Trait
High blood sugar
Clinical name: Hyperglycemia
An increased concentration of glucose in the blood.
Summary
- Also called
- High blood glucose
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test69 genes linked to High blood sugar
Changes in these genes cause rare conditions in which High blood sugar is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 5 conditions |
| ADRA2Aadrenoceptor alpha 2A | Always | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Always | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Always | In 1 condition |
| CYC1cytochrome c1 | Always | In 1 condition |
| GCSHglycine cleavage system protein H | Always | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Always | In 7 conditions |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| PAX4paired box 4 | Always | In 2 conditions |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Always | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Always | In 1 condition |
| PTF1Apancreas associated transcription factor 1a | Always | In 1 condition |
| WRNWRN RecQ like helicase | Always | In 1 condition |
| GCKglucokinase | Very often (80–99%) | In 3 conditions |
| HYMAIhydatidiform mole associated and imprinted | Very often (80–99%) | In 2 conditions |
| INSinsulin | Very often (80–99%) | In 5 conditions |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| PDX1pancreatic and duodenal homeobox 1 | Very often (80–99%) | In 2 conditions |
| PLAGL1PLAG1 like zinc finger 1 | Very often (80–99%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Very often (80–99%) | In 1 condition |
| ZFP57ZFP57 zinc finger protein | Very often (80–99%) | In 2 conditions |
| APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Often (30–79%) | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Often (30–79%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Often (30–79%) | In 1 condition |
| CELcarboxyl ester lipase | Often (30–79%) | In 2 conditions |
| HFEhomeostatic iron regulator | Often (30–79%) | In 1 condition |
| HNF1AHNF1 homeobox A | Often (30–79%) | In 3 conditions |
| HNF4Ahepatocyte nuclear factor 4 alpha | Often (30–79%) | In 1 condition |
| KLF11KLF transcription factor 11 | Often (30–79%) | In 1 condition |
| NEUROD1neuronal differentiation 1 | Often (30–79%) | In 1 condition |
| NEUROG3neurogenin 3 | Often (30–79%) | In 1 condition |
| PPARGperoxisome proliferator activated receptor gamma | Often (30–79%) | In 1 condition |
| RIMS2regulating synaptic membrane exocytosis 2 | Often (30–79%) | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Often (30–79%) | In 1 condition |
| ACAT1acetyl-CoA acetyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| AFF4ALF transcription elongation factor 4 | Sometimes (5–29%) | In 1 condition |
| DLSTdihydrolipoamide S-succinyltransferase | Sometimes (5–29%) | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Sometimes (5–29%) | In 1 condition |
| DYRK1Bdual specificity tyrosine phosphorylation regulated kinase 1B | Sometimes (5–29%) | In 1 condition |
Show 29 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| EPAS1endothelial PAS domain protein 1 | Sometimes (5–29%) | In 1 condition |
| FHfumarate hydratase | Sometimes (5–29%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 1 condition |
| KIF1Bkinesin family member 1B | Sometimes (5–29%) | In 1 condition |
| MAXMYC associated transcriptional regulator X | Sometimes (5–29%) | In 1 condition |
| MDH2malate dehydrogenase 2 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| RETret proto-oncogene | Sometimes (5–29%) | In 2 conditions |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Sometimes (5–29%) | In 1 condition |
| SDHAF2succinate dehydrogenase complex assembly factor 2 | Sometimes (5–29%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Sometimes (5–29%) | In 2 conditions |
| SDHCsuccinate dehydrogenase complex subunit C | Sometimes (5–29%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Sometimes (5–29%) | In 2 conditions |
| SLC25A11solute carrier family 25 member 11 | Sometimes (5–29%) | In 1 condition |
| TMEM127transmembrane protein 127 | Sometimes (5–29%) | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Sometimes (5–29%) | In 2 conditions |
| ARMC5armadillo repeat containing 5 | Not recorded | In 1 condition |
| GATA6GATA binding protein 6 | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| INSRinsulin receptor | Not recorded | In 2 conditions |
| KHKketohexokinase | Not recorded | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Not recorded | In 1 condition |
| NOTCH3notch receptor 3 | Not recorded | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Not recorded | In 1 condition |
| RFX6regulatory factor X6 | Not recorded | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Not recorded | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Not recorded | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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