Trait
Left ventricular systolic dysfunction
Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Read the genes linked to Left ventricular systolic dysfunction, and the rest of your genome, with one test.
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Get my Genome Test64 genes linked to Left ventricular systolic dysfunction
Changes in these genes cause rare conditions in which Left ventricular systolic dysfunction is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SDHDsuccinate dehydrogenase complex subunit D | Always | In 1 condition |
| SLC6A6solute carrier family 6 member 6 | Always | In 1 condition |
| SOX17SRY-box transcription factor 17 | Always | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Very often (80–99%) | In 2 conditions |
| ACTC1actin alpha cardiac muscle 1 | Very often (80–99%) | In 1 condition |
| ACTN2actinin alpha 2 | Very often (80–99%) | In 1 condition |
| ANKRD1ankyrin repeat domain 1 | Very often (80–99%) | In 1 condition |
| BAG3BAG cochaperone 3 | Very often (80–99%) | In 1 condition |
| BAG5BAG cochaperone 5 | Very often (80–99%) | In 1 condition |
| CAP2cyclase associated actin cytoskeleton regulatory protein 2 | Very often (80–99%) | In 1 condition |
| CRYABcrystallin alpha B | Very often (80–99%) | In 1 condition |
| CSRP3cysteine and glycine rich protein 3 | Very often (80–99%) | In 1 condition |
| DESdesmin | Very often (80–99%) | In 1 condition |
| DMDdystrophin | Very often (80–99%) | In 1 condition |
| DOLKdolichol kinase | Very often (80–99%) | In 1 condition |
| DSG2desmoglein 2 | Very often (80–99%) | In 1 condition |
| DSPdesmoplakin | Very often (80–99%) | In 1 condition |
| FHL2four and a half LIM domains 2 | Very often (80–99%) | In 1 condition |
| FKTNfukutin | Very often (80–99%) | In 1 condition |
| FLNCfilamin C | Very often (80–99%) | In 1 condition |
| GATAD1GATA zinc finger domain containing 1 | Very often (80–99%) | In 1 condition |
| GET3guided entry of tail-anchored proteins factor 3, ATPase | Very often (80–99%) | In 1 condition |
| HAND2heart and neural crest derivatives expressed 2 | Very often (80–99%) | In 1 condition |
| JPH2junctophilin 2 | Very often (80–99%) | In 1 condition |
| LAMA4laminin subunit alpha 4 | Very often (80–99%) | In 1 condition |
| LDB3LIM domain binding 3 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| LMOD2leiomodin 2 | Very often (80–99%) | In 1 condition |
| MYBPC3myosin binding protein C3 | Very often (80–99%) | In 1 condition |
| MYH6myosin heavy chain 6 | Very often (80–99%) | In 1 condition |
| MYH7myosin heavy chain 7 | Very often (80–99%) | In 1 condition |
| MYPNmyopalladin | Very often (80–99%) | In 1 condition |
| NEXNnexilin F-actin binding protein | Very often (80–99%) | In 1 condition |
| NRAPnebulin related anchoring protein | Very often (80–99%) | In 1 condition |
| PLNphospholamban | Very often (80–99%) | In 1 condition |
| PPCSphosphopantothenoylcysteine synthetase | Very often (80–99%) | In 1 condition |
| PPP1R13Lprotein phosphatase 1 regulatory subunit 13 like | Very often (80–99%) | In 1 condition |
| PRDM16PR/SET domain 16 | Very often (80–99%) | In 2 conditions |
| PSEN1presenilin 1 | Very often (80–99%) | In 1 condition |
| PSEN2presenilin 2 | Very often (80–99%) | In 1 condition |
Show 24 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Very often (80–99%) | In 1 condition |
| RBM20RNA binding motif protein 20 | Very often (80–99%) | In 2 conditions |
| RPL3Lribosomal protein L3 like | Very often (80–99%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Very often (80–99%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Very often (80–99%) | In 1 condition |
| SGCDsarcoglycan delta | Very often (80–99%) | In 1 condition |
| TAF1ATATA-box binding protein associated factor, RNA polymerase I subunit A | Very often (80–99%) | In 1 condition |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Very often (80–99%) | In 1 condition |
| TCAPtitin-cap | Very often (80–99%) | In 1 condition |
| TMPOthymopoietin | Very often (80–99%) | In 1 condition |
| TNNC1troponin C1, slow skeletal and cardiac type | Very often (80–99%) | In 1 condition |
| TNNI3troponin I3, cardiac type | Very often (80–99%) | In 1 condition |
| TNNT2troponin T2, cardiac type | Very often (80–99%) | In 1 condition |
| TPM1tropomyosin 1 | Very often (80–99%) | In 1 condition |
| TTNtitin | Very often (80–99%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Very often (80–99%) | In 1 condition |
| VCLvinculin | Very often (80–99%) | In 1 condition |
| VEZF1vascular endothelial zinc finger 1 | Very often (80–99%) | In 1 condition |
| ABCC6ATP binding cassette subfamily C member 6 | Often (30–79%) | In 1 condition |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Sometimes (5–29%) | In 2 conditions |
| POPDC2popeye domain cAMP effector 2 | Sometimes (5–29%) | In 1 condition |
| SGCGsarcoglycan gamma | Sometimes (5–29%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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