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Trait
Spastic tetraparesis
Spastic weakness affecting all four limbs.
Summary
- Also called
- Spastic quadriparesis
Spastic tetraparesisHP:0001285
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Read the genes linked to Spastic tetraparesis, and the rest of your genome, with one test.
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Get my Genome Test81 genes linked to Spastic tetraparesis
Changes in these genes cause rare conditions in which Spastic tetraparesis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG3ALG3 alpha-1,3- mannosyltransferase | Always | In 2 conditions |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Always | In 3 conditions |
| EIF4A2eukaryotic translation initiation factor 4A2 | Always | In 1 condition |
| ELFN1extracellular leucine rich repeat and fibronectin type III domain containing 1 | Always | In 1 condition |
| ESAMendothelial cell adhesion molecule | Always | In 1 condition |
| FAR1fatty acyl-CoA reductase 1 | Always | In 2 conditions |
| LIPT1lipoyltransferase 1 | Always | In 1 condition |
| LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated | Always | In 1 condition |
| LYRM7LYR motif containing 7 | Always | In 1 condition |
| MED16mediator complex subunit 16 | Always | In 1 condition |
| MFSD2AMFSD2 lysolipid transporter A, lysophospholipid | Always | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Always | In 1 condition |
| MRM2mitochondrial rRNA methyltransferase 2 | Always | In 1 condition |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Always | In 1 condition |
| PHACTR1phosphatase and actin regulator 1 | Always | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Always | In 1 condition |
| SOD1superoxide dismutase 1 | Always | In 1 condition |
| TNRtenascin R | Always | In 1 condition |
| COA8cytochrome c oxidase assembly factor 8 | Very often (80–99%) | In 2 conditions |
| ERLIN2ER lipid raft associated 2 | Very often (80–99%) | In 1 condition |
| PRUNE1prune exopolyphosphatase 1 | Very often (80–99%) | In 2 conditions |
| SLC18A2solute carrier family 18 member A2 | Very often (80–99%) | In 1 condition |
| STAMBPSTAM binding protein | Very often (80–99%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Often (30–79%) | In 1 condition |
| ARXaristaless related homeobox | Often (30–79%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Often (30–79%) | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Often (30–79%) | In 1 condition |
| EARS2glutamyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| EXOSC8exosome component 8 | Often (30–79%) | In 1 condition |
| FA2Hfatty acid 2-hydroxylase | Often (30–79%) | In 2 conditions |
| FBLN1fibulin 1 | Often (30–79%) | In 1 condition |
| GUF1GTP binding elongation factor GUF1 | Often (30–79%) | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Often (30–79%) | In 1 condition |
| KCNJ6potassium inwardly rectifying channel subfamily J member 6 | Often (30–79%) | In 2 conditions |
| L2HGDHL-2-hydroxyglutarate dehydrogenase | Often (30–79%) | In 2 conditions |
| LIPT2lipoyl(octanoyl) transferase 2 | Often (30–79%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Often (30–79%) | In 1 condition |
| NUP54nucleoporin 54 | Often (30–79%) | In 1 condition |
Show 41 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NUP62nucleoporin 62 | Often (30–79%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Often (30–79%) | In 1 condition |
| PLP1proteolipid protein 1 | Often (30–79%) | In 2 conditions |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Often (30–79%) | In 1 condition |
| SNAPC4small nuclear RNA activating complex polypeptide 4 | Often (30–79%) | In 1 condition |
| AASSaminoadipate-semialdehyde synthase | Sometimes (5–29%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 1 condition |
| AFF3ALF transcription elongation factor 3 | Sometimes (5–29%) | In 1 condition |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Sometimes (5–29%) | In 1 condition |
| DYMdymeclin | Sometimes (5–29%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Sometimes (5–29%) | In 1 condition |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| PRDM8PR/SET domain 8 | Sometimes (5–29%) | In 1 condition |
| PSAT1phosphoserine aminotransferase 1 | Sometimes (5–29%) | In 1 condition |
| REEP1receptor accessory protein 1 | Sometimes (5–29%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Sometimes (5–29%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Sometimes (5–29%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Sometimes (5–29%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Sometimes (5–29%) | In 1 condition |
| SLC35A2solute carrier family 35 member A2 | Sometimes (5–29%) | In 1 condition |
| SOX4SRY-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| STXBP1syntaxin binding protein 1 | Sometimes (5–29%) | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| TBCEtubulin folding cofactor E | Sometimes (5–29%) | In 1 condition |
| TMEM222transmembrane protein 222 | Sometimes (5–29%) | In 1 condition |
| AHDC1AT-hook DNA binding motif containing 1 | Rarely (1–4%) | In 1 condition |
| APOEapolipoprotein E | Not recorded | In 1 condition |
| EIF2S3eukaryotic translation initiation factor 2 subunit gamma | Not recorded | In 1 condition |
| GM2Aganglioside GM2 activator | Not recorded | In 1 condition |
| GSSglutathione synthetase | Not recorded | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Not recorded | In 1 condition |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Not recorded | In 1 condition |
| MOCS1molybdenum cofactor synthesis 1 | Not recorded | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Not recorded | In 1 condition |
| PSAPprosaposin | Not recorded | In 1 condition |
| PSEN1presenilin 1 | Not recorded | In 1 condition |
| TRAPPC4trafficking protein particle complex subunit 4 | Not recorded | In 1 condition |
| WDR62WD repeat domain 62 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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