Trait
Left ventricular noncompaction
Left ventricular noncompaction (LVNC) is defined by 3 markers: prominent left ventricular (LV) trabeculae, deep intertrabecular recesses, and the thin compacted layer.
Summary
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
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Get my Genome Test20 genes linked to Left ventricular noncompaction
Changes in these genes cause rare conditions in which Left ventricular noncompaction is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COA6cytochrome c oxidase assembly factor 6 | Always | In 1 condition |
| DTNAdystrobrevin alpha | Always | In 1 condition |
| LDB3LIM domain binding 3 | Always | In 2 conditions |
| MIPEPmitochondrial intermediate peptidase | Always | In 1 condition |
| MYBPC3myosin binding protein C3 | Always | In 1 condition |
| NRAPnebulin related anchoring protein | Always | In 1 condition |
| PRDM16PR/SET domain 16 | Always | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Always | In 1 condition |
| TNNT2troponin T2, cardiac type | Always | In 1 condition |
| VARS2valyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| MYH7myosin heavy chain 7 | Very often (80–99%) | In 1 condition |
| HCN4hyperpolarization activated cyclic nucleotide gated potassium channel 4 | Often (30–79%) | In 1 condition |
| NPPAnatriuretic peptide A | Often (30–79%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 2 conditions |
| ACTC1actin alpha cardiac muscle 1 | Sometimes (5–29%) | In 1 condition |
| ACTN2actinin alpha 2 | Sometimes (5–29%) | In 1 condition |
| CALM2calmodulin 2 | Sometimes (5–29%) | In 1 condition |
| MIB1MIB E3 ubiquitin protein ligase 1 | Not recorded | In 1 condition |
| NONOnon-POU domain containing octamer binding | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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