Trait
Brisk knee jerk
Clinical name: Hyperactive patellar reflex
Summary
- Also called
- Overactive knee reflex, Hyperreflexia in knees
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test20 genes linked to Brisk knee jerk
Changes in these genes cause rare conditions in which Brisk knee jerk is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANO10anoctamin 10 | Always | In 1 condition |
| ARL6IP1ARL6 interacting reticulophagy regulator 1 | Always | In 2 conditions |
| HARS1histidyl-tRNA synthetase 1 | Always | In 2 conditions |
| SACSsacsin molecular chaperone | Always | In 1 condition |
| SIGMAR1sigma receptor chaperone 1 | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| TUBA4Atubulin alpha 4a | Always | In 1 condition |
| MTPAPmitochondrial poly(A) polymerase | Very often (80–99%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Often (30–79%) | In 1 condition |
| COX4I1cytochrome c oxidase subunit 4I1 | Often (30–79%) | In 1 condition |
| HEXBhexosaminidase subunit beta | Often (30–79%) | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Often (30–79%) | In 1 condition |
| PNPLA6patatin like domain 6, lysophospholipase | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Sometimes (5–29%) | In 1 condition |
| NONOnon-POU domain containing octamer binding | Sometimes (5–29%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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