Trait
Progressive degeneration of movement
Clinical name: Motor deterioration
Loss of previously present motor (i.e., movement) abilities.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Progressive degeneration of movement, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test21 genes linked to Progressive degeneration of movement
Changes in these genes cause rare conditions in which Progressive degeneration of movement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GPRC5BG protein-coupled receptor class C group 5 member B | Always | In 2 conditions |
| MECP2methyl-CpG binding protein 2 | Always | In 1 condition |
| PDHA1pyruvate dehydrogenase E1 subunit alpha 1 | Always | In 1 condition |
| PSAPprosaposin | Always | In 1 condition |
| RBM28RNA binding motif protein 28 | Always | In 2 conditions |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Very often (80–99%) | In 1 condition |
| AQP4aquaporin 4 | Often (30–79%) | In 1 condition |
| CLN8CLN8 transmembrane ER and ERGIC protein | Often (30–79%) | In 1 condition |
| HEPACAMhepatic and glial cell adhesion molecule | Often (30–79%) | In 1 condition |
| HGSNATheparan-alpha-glucosaminide N-acetyltransferase | Often (30–79%) | In 1 condition |
| MLC1modulator of VRAC current 1 | Often (30–79%) | In 1 condition |
| PLEKHG4pleckstrin homology and RhoGEF domain containing G4 | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| CLN5CLN5 lysosomal BMP synthase | Not recorded | In 1 condition |
| CLN6CLN6 transmembrane ER protein | Not recorded | In 1 condition |
| GALCgalactosylceramidase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks