Trait
Instability or lack of coordination of central trunk muscles
Clinical name: Truncal ataxia
Truncal ataxia is a sign of ataxia characterized by instability of the trunk. It usually occurs during sitting.
Summary
- Also called
- Trunk ataxia
- Body system
- Abnormality of the nervous system
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Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
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Show 46 more reports
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- POLR3A-Related DisorderReads 1 of these genesPOLR3AAbout this report →
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- UNC13A-Related Neurodevelopmental DisordersReads 1 of these genesUNC13AAbout this report →
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- Epilepsy (Full Panel)Reads 6 of these genesCERS1KCTD7PIGACACNA1AATP1A3MECP2About this report →
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- Malignant Endocrine NeoplasmReads 1 of these genesSDHAAbout this report →
- Charcot-Marie-Tooth DiseaseReads 3 of these genesHARS1SCO2SURF1About this report →
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Read the genes linked to Instability or lack of coordination of central trunk muscles, and the rest of your genome, with one test.
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Get my Genome Test87 genes linked to Instability or lack of coordination of central trunk muscles
Changes in these genes cause rare conditions in which Instability or lack of coordination of central trunk muscles is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADGRG1adhesion G protein-coupled receptor G1 | Always | In 1 condition |
| ASPNATaspartate N-acetyltransferase | Always | In 1 condition |
| ATG5autophagy related 5 | Always | In 1 condition |
| ATP8A2ATPase phospholipid transporting 8A2 | Always | In 1 condition |
| CERS1ceramide synthase 1 | Always | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Always | In 1 condition |
| COX15cytochrome c oxidase assembly factor COX15 | Always | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Always | In 2 conditions |
| CWF19L1CWF19 like cell cycle control factor 1 | Always | In 2 conditions |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Always | In 1 condition |
| GRID2glutamate ionotropic receptor delta type subunit 2 | Always | In 2 conditions |
| HARS1histidyl-tRNA synthetase 1 | Always | In 1 condition |
| HIBCH3-hydroxyisobutyryl-CoA hydrolase | Always | In 2 conditions |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 2 conditions |
| KCTD7potassium channel tetramerization domain containing 7 | Always | In 1 condition |
| MOCS3molybdenum cofactor synthesis 3 | Always | In 1 condition |
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Always | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Always | In 1 condition |
| NOP56NOP56 ribonucleoprotein | Always | In 2 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 1 condition |
| POLR1ARNA polymerase I subunit A | Always | In 1 condition |
| RNU12RNA, U12 small nuclear | Always | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Always | In 2 conditions |
| SLC1A3solute carrier family 1 member 3 | Always | In 1 condition |
| STUB1STIP1 homology and U-box containing protein 1 | Always | In 2 conditions |
| SURF1SURF1 cytochrome c oxidase assembly factor | Always | In 1 condition |
| SYT14synaptotagmin 14 | Always | In 2 conditions |
| TACO1translational activator of cytochrome c oxidase I | Always | In 1 condition |
| TTBK2tau tubulin kinase 2 | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 1 condition |
| UROC1urocanate hydratase 1 | Always | In 2 conditions |
| VLDLRvery low density lipoprotein receptor | Always | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Very often (80–99%) | In 2 conditions |
| VPS13Dvacuolar protein sorting 13 homolog D | Very often (80–99%) | In 1 condition |
| VPS41VPS41 subunit of HOPS complex | Very often (80–99%) | In 1 condition |
| ANO10anoctamin 10 | Often (30–79%) | In 2 conditions |
| AP2M1adaptor related protein complex 2 subunit mu 1 | Often (30–79%) | In 1 condition |
Show 47 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATCAYATCAY kinesin light chain interacting caytaxin | Often (30–79%) | In 2 conditions |
| ATN1atrophin 1 | Often (30–79%) | In 1 condition |
| ATP2B3ATPase plasma membrane Ca2+ transporting 3 | Often (30–79%) | In 1 condition |
| CACNB4calcium voltage-gated channel auxiliary subunit beta 4 | Often (30–79%) | In 3 conditions |
| CEP120centrosomal protein 120 | Often (30–79%) | In 1 condition |
| DAB1DAB adaptor protein 1 | Often (30–79%) | In 1 condition |
| EBF3EBF transcription factor 3 | Often (30–79%) | In 1 condition |
| EEF2eukaryotic translation elongation factor 2 | Often (30–79%) | In 2 conditions |
| EIF2AK2eukaryotic translation initiation factor 2 alpha kinase 2 | Often (30–79%) | In 1 condition |
| FGF14fibroblast growth factor 14 | Often (30–79%) | In 1 condition |
| KCND3potassium voltage-gated channel subfamily D member 3 | Often (30–79%) | In 2 conditions |
| NDUFA13NADH:ubiquinone oxidoreductase subunit A13 | Often (30–79%) | In 1 condition |
| NKX6-2NK6 homeobox 2 | Often (30–79%) | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Often (30–79%) | In 1 condition |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 2 conditions |
| SLC25A15solute carrier family 25 member 15 | Often (30–79%) | In 1 condition |
| SPTBN2spectrin beta, non-erythrocytic 2 | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 3 conditions |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Sometimes (5–29%) | In 1 condition |
| COG5component of oligomeric golgi complex 5 | Sometimes (5–29%) | In 2 conditions |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Sometimes (5–29%) | In 1 condition |
| DOHHdeoxyhypusine hydroxylase | Sometimes (5–29%) | In 1 condition |
| GBA2glucosylceramidase beta 2 | Sometimes (5–29%) | In 2 conditions |
| LRPPRCleucine rich pentatricopeptide repeat containing | Sometimes (5–29%) | In 1 condition |
| MAST1microtubule associated serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Sometimes (5–29%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| SHMT2serine hydroxymethyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| SLC30A10solute carrier family 30 member 10 | Sometimes (5–29%) | In 1 condition |
| SLC52A3solute carrier family 52 member 3 | Sometimes (5–29%) | In 1 condition |
| TPK1thiamin pyrophosphokinase 1 | Sometimes (5–29%) | In 1 condition |
| TTRtransthyretin | Sometimes (5–29%) | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Rarely (1–4%) | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Rarely (1–4%) | In 1 condition |
| ZIC1Zic family zinc finger 1 | Rarely (1–4%) | In 1 condition |
| ZIC4Zic family zinc finger 4 | Rarely (1–4%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Not recorded | In 1 condition |
| ATXN1ataxin 1 | Not recorded | In 1 condition |
| ATXN3ataxin 3 | Not recorded | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Not recorded | In 1 condition |
| MSTO1misato mitochondrial distribution and morphology regulator 1 | Not recorded | In 1 condition |
| PRNPprion protein (Kanno blood group) | Not recorded | In 1 condition |
| VWA3Bvon Willebrand factor A domain containing 3B | Not recorded | In 1 condition |
| WDR81WD repeat domain 81 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
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