Trait

Communication delay

Clinical name: Expressive language delay

A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.

HPO HP:0002474

Also called: Deficit in expressive language
Body system: Abnormality of the nervous system

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48 genes linked to Communication delay

Changes in these genes cause rare conditions in which Communication delay is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ATXN7L3ataxin 7 like 3	Always	In 1 condition
DNM1Ldynamin 1L	Always	In 1 condition
MAU2MAU2 sister chromatid cohesion factor	Always	In 1 condition
MED23mediator complex subunit 23	Always	In 1 condition
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1	Always	In 1 condition
SLC25A36solute carrier family 25 member 36	Always	In 1 condition
SRCAPSnf2 related CREBBP activator protein	Always	In 1 condition
STAG2STAG2 cohesin complex component	Always	In 1 condition
TAF4TATA-box binding protein associated factor 4	Always	In 1 condition
WARS2tryptophanyl tRNA synthetase 2, mitochondrial	Always	In 1 condition
YARS1tyrosyl-tRNA synthetase 1	Always	In 1 condition
YME1L1YME1 like 1 ATPase	Always	In 1 condition
FOXP1forkhead box P1	Very often (80–99%)	In 1 condition
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Very often (80–99%)	In 1 condition
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta	Very often (80–99%)	In 1 condition
RAI1retinoic acid induced 1	Very often (80–99%)	In 2 conditions
ZEB2zinc finger E-box binding homeobox 2	Very often (80–99%)	In 2 conditions
AHDC1AT-hook DNA binding motif containing 1	Often (30–79%)	In 1 condition
CDONcell adhesion associated, oncogene regulated	Often (30–79%)	In 1 condition
CRIPTOcripto, EGF-CFC family member	Often (30–79%)	In 1 condition
DISP1dispatched RND transporter family member 1	Often (30–79%)	In 1 condition
DLL1delta like canonical Notch ligand 1	Often (30–79%)	In 1 condition
FGF8fibroblast growth factor 8	Often (30–79%)	In 1 condition
FOXH1forkhead box H1	Often (30–79%)	In 1 condition
FOXP2forkhead box P2	Often (30–79%)	In 1 condition
GAS1growth arrest specific 1	Often (30–79%)	In 1 condition
GLI2GLI family zinc finger 2	Often (30–79%)	In 1 condition
GNB1G protein subunit beta 1	Often (30–79%)	In 2 conditions
NODALnodal growth differentiation factor	Often (30–79%)	In 1 condition
PTCH1patched 1	Often (30–79%)	In 1 condition
PUF60poly(U) binding splicing factor 60	Often (30–79%)	In 1 condition
SCN4Asodium voltage-gated channel alpha subunit 4	Often (30–79%)	In 2 conditions
SHHsonic hedgehog signaling molecule	Often (30–79%)	In 1 condition
SIX3SIX homeobox 3	Often (30–79%)	In 1 condition
STILSTIL centriolar assembly protein	Often (30–79%)	In 1 condition
TGIF1TGFB induced factor homeobox 1	Often (30–79%)	In 1 condition
TNNT1troponin T1, slow skeletal type	Often (30–79%)	In 1 condition
TUBB3tubulin beta 3 class III	Often (30–79%)	In 1 condition
ZIC2Zic family zinc finger 2	Often (30–79%)	In 1 condition
KMT2Dlysine methyltransferase 2D	Sometimes (5–29%)	In 1 condition

Show 8 more genes

Gene	How often it is seen	Conditions
MSL2MSL complex subunit 2	Sometimes (5–29%)	In 1 condition
SDHAsuccinate dehydrogenase complex flavoprotein subunit A	Sometimes (5–29%)	In 1 condition
SDHAF1succinate dehydrogenase complex assembly factor 1	Sometimes (5–29%)	In 1 condition
SDHBsuccinate dehydrogenase complex iron sulfur subunit B	Sometimes (5–29%)	In 1 condition
SDHDsuccinate dehydrogenase complex subunit D	Sometimes (5–29%)	In 1 condition
SHMT2serine hydroxymethyltransferase 2	Sometimes (5–29%)	In 1 condition
FLCNfolliculin	Not recorded	In 1 condition
NSD1nuclear receptor binding SET domain protein 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Delayed speech and language development

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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