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Trait

Reduced left ventricular ejection fraction

A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.

HPO HP:0012664

Summary

Also called
Reduced ejection fraction
Body system
Abnormality of the cardiovascular system

39 genes linked to Reduced left ventricular ejection fraction

Changes in these genes cause rare conditions in which Reduced left ventricular ejection fraction is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AARS2alanyl-tRNA synthetase 2, mitochondrialAlwaysIn 1 condition
ABCC6ATP binding cassette subfamily C member 6AlwaysIn 1 condition
COA6cytochrome c oxidase assembly factor 6AlwaysIn 1 condition
CSRP3cysteine and glycine rich protein 3AlwaysIn 1 condition
FKTNfukutinAlwaysIn 1 condition
GATAD1GATA zinc finger domain containing 1AlwaysIn 1 condition
GET3guided entry of tail-anchored proteins factor 3, ATPaseAlwaysIn 1 condition
LAMA4laminin subunit alpha 4AlwaysIn 1 condition
LDB3LIM domain binding 3AlwaysIn 1 condition
LMNAlamin A/CAlwaysIn 1 condition
MYH6myosin heavy chain 6AlwaysIn 1 condition
NEXNnexilin F-actin binding proteinAlwaysIn 1 condition
RAF1Raf-1 proto-oncogene, serine/threonine kinaseAlwaysIn 1 condition
RPL3Lribosomal protein L3 likeAlwaysIn 1 condition
SDHAsuccinate dehydrogenase complex flavoprotein subunit AAlwaysIn 1 condition
SGCDsarcoglycan deltaAlwaysIn 1 condition
TNNT2troponin T2, cardiac typeAlwaysIn 2 conditions
VEZF1vascular endothelial zinc finger 1AlwaysIn 1 condition
MYH7myosin heavy chain 7Very often (80–99%)In 1 condition
RRAGDRas related GTP binding DVery often (80–99%)In 1 condition
SCN5Asodium voltage-gated channel alpha subunit 5Very often (80–99%)In 2 conditions
ACADVLacyl-CoA dehydrogenase very long chainOften (30–79%)In 1 condition
DESdesminOften (30–79%)In 1 condition
MYBPC3myosin binding protein C3Often (30–79%)In 1 condition
NPPAnatriuretic peptide AOften (30–79%)In 1 condition
TTRtransthyretinOften (30–79%)In 1 condition
VCLvinculinOften (30–79%)In 1 condition
B2Mbeta-2-microglobulinSometimes (5–29%)In 1 condition
DYSFdysferlinSometimes (5–29%)In 1 condition
FHOD3formin homology 2 domain containing 3Sometimes (5–29%)In 1 condition
LAMA2laminin subunit alpha 2Sometimes (5–29%)In 1 condition
POLGDNA polymerase gamma, catalytic subunitSometimes (5–29%)In 1 condition
POLG2DNA polymerase gamma 2, accessory subunitSometimes (5–29%)In 1 condition
PSEN2presenilin 2Sometimes (5–29%)In 1 condition
RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2BSometimes (5–29%)In 1 condition
SLC25A4solute carrier family 25 member 4Sometimes (5–29%)In 1 condition
TWNKtwinkle mtDNA helicaseSometimes (5–29%)In 1 condition
PPCSphosphopantothenoylcysteine synthetaseNot recordedIn 1 condition
TTNtitinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal left ventricular ejection fractionLeft ventricular systolic dysfunction

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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