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Trait

Abnormal pyramidal tract morphology

Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts.

HPO HP:0002062

Summary

Also called
Abnormality of the pyramidal tracts, Morphological abnormality of the pyramidal tract
Body system
Abnormality of the nervous system

20 genes linked to Abnormal pyramidal tract morphology

Changes in these genes cause rare conditions in which Abnormal pyramidal tract morphology is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AIFM1apoptosis inducing factor mitochondria associated 1Often (30–79%)In 1 condition
PRNPprion protein (Kanno blood group)Often (30–79%)In 1 condition
GALCgalactosylceramidaseSometimes (5–29%)In 1 condition
ATXN10ataxin 10Not recordedIn 1 condition
ATXN8ataxin 8Not recordedIn 1 condition
ATXN8OSATXN8 opposite strand lncRNANot recordedIn 1 condition
CTC1CST telomere replication complex component 1Not recordedIn 1 condition
DPYSdihydropyrimidinaseNot recordedIn 1 condition
FXNfrataxinNot recordedIn 1 condition
GANgigaxoninNot recordedIn 1 condition
KCNC3potassium voltage-gated channel subfamily C member 3Not recordedIn 1 condition
L2HGDHL-2-hydroxyglutarate dehydrogenaseNot recordedIn 1 condition
MAPTmicrotubule associated protein tauNot recordedIn 1 condition
PLA2G6phospholipase A2 group VINot recordedIn 1 condition
PRKRAprotein activator of interferon induced protein kinase EIF2AK2Not recordedIn 1 condition
SLC19A3solute carrier family 19 member 3Not recordedIn 1 condition
SLC2A1solute carrier family 2 member 1Not recordedIn 1 condition
SLC6A3solute carrier family 6 member 3Not recordedIn 1 condition
TREX1three prime repair exonuclease 1Not recordedIn 1 condition
VAPBVAMP associated protein B and CNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Morphological central nervous system abnormality

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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