Trait
Inappropriate laughter
Laughing that may be excessive and/or inappropriate in context (e.g., laughing at a funeral while others are crying).
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test27 genes linked to Inappropriate laughter
Changes in these genes cause rare conditions in which Inappropriate laughter is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MBD5methyl-CpG binding domain protein 5 | Always | In 1 condition |
| NOTCH3notch receptor 3 | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 1 condition |
| ATP10AATPase phospholipid transporting 10A (putative) | Often (30–79%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Often (30–79%) | In 1 condition |
| NOVA2NOVA alternative splicing regulator 2 | Often (30–79%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 1 condition |
| PDE2Aphosphodiesterase 2A | Often (30–79%) | In 1 condition |
| PGAP1post-GPI attachment to proteins inositol deacylase 1 | Often (30–79%) | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Often (30–79%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Often (30–79%) | In 1 condition |
| TBC1D2BTBC1 domain family member 2B | Often (30–79%) | In 1 condition |
| UBE3Aubiquitin protein ligase E3A | Often (30–79%) | In 3 conditions |
| CDKL5cyclin dependent kinase like 5 | Sometimes (5–29%) | In 1 condition |
| CSF1Rcolony stimulating factor 1 receptor | Sometimes (5–29%) | In 1 condition |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Sometimes (5–29%) | In 1 condition |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Sometimes (5–29%) | In 1 condition |
| GATAD2BGATA zinc finger domain containing 2B | Sometimes (5–29%) | In 2 conditions |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| NTNG1netrin G1 | Sometimes (5–29%) | In 1 condition |
| PIGSphosphatidylinositol glycan anchor biosynthesis class S | Sometimes (5–29%) | In 1 condition |
| SLC6A17solute carrier family 6 member 17 | Sometimes (5–29%) | In 2 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 1 condition |
| YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | Sometimes (5–29%) | In 1 condition |
| ADSLadenylosuccinate lyase | Not recorded | In 1 condition |
| MAPTmicrotubule associated protein tau | Not recorded | In 2 conditions |
| PSEN1presenilin 1 | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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