Gen
HSPG2
heparan sulfate proteoglycan 2
- HGNC 5273↗(åbnes i en ny fane)
- Ensembl-gen ENSG00000142798↗(åbnes i en ny fane)
- NCBI Gene 3339↗(åbnes i en ny fane)
Oversigt
- Cytogenetisk placering
- 1p36.12
- Koordinater
- Kromosom 1: 21.822.244–21.937.310 (GRCh38)
- Exoner
- 97 exoner fordelt over 115,1 kb
- Protein
- 4.391 aminosyrer
- Også kendt som
- perlecan, PRCAN
- Tidligere symboler
- SJS1
- MANE Select-transkript
- ENST00000374695.8NM_005529.7
- Lokustype
- Protein-coding
This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/genes/hspg2.json"
page <- fromJSON(url)
page$gene$nameLæs HSPG2 og resten af dit genom med én test.
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Bestil min Genome TestKurerede rapporter relevant for dette gen
Ingen Genome Test-rapport læser HSPG2 endnu. Testen sekventerer hele dit genom, så dine data omfatter det alligevel.
Sådan er HSPG2 opbygget
- Kodende sekvens
- Utranslateret region
- Intron
- Transkriptionsretning
- Kendte sygdomsfremkaldende steder
- Regioner, som korte læsninger har svært ved
Eksoner i genets MANE Select-transkript (udgave v1.5), fra NCBI og EMBL-EBI, på referencegenomet GRCh38.
Kromosombånd fra UCSC's GRCh38-ideogram (2022-10-29).
Gener i nærheden fra Ensembl-udgivelse 116, på GRCh38.
Eksoner udgør 14,3 kb af genets 115,1 kb; 13.176 af disse baser koder for proteinet.
Sekventering af HSPG2
40
positioner i HSPG2, hvor ClinVar klassificerer en ændring som patogen eller sandsynligvis patogen
Ingen af dem ligger i en region, som korte læsninger har svært ved at dække.
En helgenomsanalyse dækker alle 115,1 kb af HSPG2, inklusive introner, og ikke kun de 14,3 kb eksoner.
Træk knyttet til HSPG2
Human Phenotype Ontology angiver disse som kendetegn ved de sjældne tilstande, HSPG2 kan forårsage. Hvert træks side viser de andre gener, der er knyttet til det.
Abnormality of the musculoskeletal system
- Anisospondyly
- Muscle stiffness
- Short long bone
- Small chest
- Abnormal formation of the hip
- Abnormal shape of end part of bone
- Abnormal skeletal development
- Arthrogryposis multiplex congenita
Vis 43 træk mere
- EMG abnormality
- Joint stiffness
- Low muscle tone
- Myotonia
- Spasticity and rigidity of muscles
- Abnormal bone maturation of vertebra
- Coronal cleft vertebrae
- EMG: myotonic discharges
- Excessive inward curvature of lower spine
- Flattened vertebrae
- Hunched back
- Increased skeletal muscle cells
- Limitation of joint mobility
- Muscle degeneration
- Muscle tissue disease
- Narrow chest
- Osteoporosis
- Percussion myotonia
- Pigeon chest
- Prominent swayback
- Reduced spine movement
- Rounded neck
- Scoliosis
- Shoulder flexion contracture
- Squared iliac bones
- 11 pairs of ribs
- Abnormality of the ribs
- Abnormally straight spine
- Broad long bones
- Cleft ribs
- Delayed bone maturation
- Flexed joint that cannot be straightened
- Funnel chest
- High shoulder blade
- Hypoplastic ischia
- Hypoplastic pubic bone
- Increased bone mineral density
- Kyphoscoliosis
- Muscle weakness
- Narrow spinal canal
- Rib fusion
- Short ribs
- Small wings of the pelvic girdle
Abnormality of head or neck
- Expressionless face
- Little lower jaw
- Decrease in jaw mobility
- Drooping lower lip
- Full cheeks
- Horizontal eyebrow
- Long philtrum
- Midface retrusion
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- Narrow mouth
- Pointed chin
- Pursed lips
- Wide nasal bridge
- Abnormality of the eyebrow
- Abnormally small head
- Boxer's nasal deformity
- Brain tissue sticks out through back of skull
- Broad head shape
- Cranial defect
- Deep philtrum
- Delayed cranial suture closure
- Depressed nasal bridge
- Eye folds
- Flat face
- Flat nose
- High palate
- Narrow eyelid opening
- Narrow opening between the eyelids
- Prominent nasal bridge
- Short neck
- Abnormality of the neck
- Bad bite
- Cleft palate
- Distichiasis
- Encephalocele
- Extra bones within cranial sutures
- Extra teeth
- Eyelid spasm
- Frontal bossing
- Long eyelashes in irregular rows
- Low frontal hairline
- Odontogenic neoplasm
- Zygomatic flattening
Abnormality of limbs
- Abnormality of the wide portion of a long bone
- Bowing of the long bones
- Dropped arches
- Knock knees
- Metatarsus valgus
- Permanent flexion of the finger
- Short fingers or toes
- Short foot
Vis 22 træk mere
- Smaller or shorter than typical limbs
- Abnormality of limbs
- Bowed legs
- Club feet
- Coxa valga
- Coxa vara
- Curvature of little finger
- Flexion contracture of toe
- Hip contracture
- Limb undergrowth
- Quadriceps weakness
- Wrist flexion contracture
- Abnormally indented hip sockets
- Clubbing of fingers
- Duplication of bones of the toes
- Elbow dislocation
- Left and right leg differ in length or width
- Abnormality of thighbone end part
- Anterior bowing of long bones
- Broad wide portion of long bone
- Dislocated hip since birth
- Joint contracture of the hand
Abnormality of the nervous system
- Abnormal gait
- Abnormal speech pattern
- Absent speech development
- Agenesis of corpus callosum
- Decrease in size of the outer layer of the brain due to loss of brain cells
- Delayed speech and language development
- EEG abnormality
- Global developmental delay
Vis 19 træk mere
- Intellectual disability
- Poor speech
- Ventriculomegaly
- Autism
- Behavioral abnormality
- Decreased reflex response
- Epilepsy
- High pitched voice
- Repetitive movements
- Self-injurious behavior
- Waddling gait
- Anxiety
- Attention deficit
- Cancer of early nerve cells
- Cranial nerve paralysis
- Increased appetite
- Irritability
- Paralysis or weakness of one side of body
- Too much cerebrospinal fluid in the brain
Abnormality of the digestive system
- Acid reflux
- Constipation
- Feeding difficulties in infancy
- Poor swallowing
- Abnormality of the anus
- Abnormality of the intestine
- Abnormality of the liver
- Annular pancreas
Vis 3 træk mere
Eksterne links
Genposter
Transkript
Protein
Hvor oplysningerne kommer fra
- HGNC: genets symbol, navn, andre symboler og placering.
- MANE Select v1.5, fra NCBI og EMBL-EBI: transkriptet, dets exoner og kodende sekvens.
- ClinVar og GIAB-stratifikationerne: kendte sygdomsfremkaldende positioner og de regioner, som korte læsninger har svært ved at aflæse.
- Human Phenotype Ontology, version 2026-09-01: de træk, der er knyttet til genet. Læs mere på hpo.jax.org.
- Dataudgivelse 2026.10.16-c6eea6bf.
Citér denne side
Dante Labs. (u.d.). HSPG2-genet: heparan sulfate proteoglycan 2. Hentet 17. oktober 2026, fra https://dantelabs.com/da/genes/hspg2
Dante Labs. HSPG2-genet: heparan sulfate proteoglycan 2 [Internet]. [citeret 17. oktober 2026]. Tilgængelig fra: https://dantelabs.com/da/genes/hspg2
Én test. Svar for hele livet.
Fra 449 $Gratis forsendelse · Resultater på 6–8 uger