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Gene

RBBP8

RB binding protein 8, endonuclease

Summary

Cytogenetic location
18q11.2
Coordinates
Chromosome 18: 22,933,328–23,026,486 (GRCh38)
Exons
19 exons across 93.2 kb
Protein
897 amino acids
Also known as
CtIP, RIM, COM1
Previous symbols
SCKL2
MANE Select transcript
ENST00000327155.10NM_002894.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RBBP8 yet. The test sequences your whole genome, so your data includes it all the same.

How RBBP8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 18, with a bracket where RBBP8 sits. RBBP8 and 3 genes near it on chromosome 18, from 22,479,907 to 23,479,906.Chromosome 1818q11.2p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q2322.6 Mb22.8 Mb23 Mb23.2 Mb23.4 MbRBBP8: 22,933,328–23,026,486, forward strandRBBP8CABLES1: 23,134,564–23,260,470, forward strandCABLES1SLC35D4: 23,197,144–23,437,976, reverse strandSLC35D4RIOK3: 23,453,265–23,486,603, forward strandRIOK3Diagram of RBBP8: 19 exons on the forward strand of chromosome 18Exon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 1: 22,933,328–22,933,564, 237 basesExon 2: 22,936,754–22,936,960, 207 basesExon 3: 22,946,444–22,946,486, 43 basesExon 4: 22,949,618–22,949,713, 96 basesExon 5: 22,968,806–22,968,918, 113 basesExon 6: 22,975,153–22,975,219, 67 basesExon 7: 22,982,218–22,982,393, 176 basesExon 8: 22,984,886–22,984,990, 105 basesExon 9: 22,989,221–22,989,318, 98 basesExon 10: 22,990,937–22,991,049, 113 basesExon 11: 22,992,748–22,993,639, 892 basesExon 12: 22,993,721–22,993,847, 127 basesExon 13: 22,996,374–22,996,462, 89 basesExon 14: 22,997,620–22,997,734, 115 basesExon 15: 23,001,586–23,001,729, 144 basesExon 16: 23,006,363–23,006,432, 70 basesExon 17: 23,016,828–23,016,924, 97 basesExon 18: 23,022,129–23,022,270, 142 basesExon 19: 23,026,143–23,026,486, 344 bases124681012141618195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 93.2 kb; 2,694 of those bases code for the protein.

How a genome test reads RBBP8

8

positions in RBBP8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 93.2 kb of RBBP8, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RBBP8 gene: RB binding protein 8, endonuclease. Retrieved 17 October 2026, from https://dantelabs.com/genes/rbbp8

Vancouver

Dante Labs. RBBP8 gene: RB binding protein 8, endonuclease [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rbbp8

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