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Gene

LRP6

LDL receptor related protein 6

Summary

Cytogenetic location
12p13.2
Coordinates
Chromosome 12: 12,116,025–12,267,044 (GRCh38)
Exons
23 exons across 151 kb
Protein
1,613 amino acids
Also known as
ADCAD2
MANE Select transcript
ENST00000261349.9NM_002336.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How LRP6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where LRP6 sits. LRP6 and 8 genes near it on chromosome 12, from 11,691,535 to 12,691,534.Chromosome 1212p13.2p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3311.8 Mb12 Mb12.2 Mb12.4 Mb12.6 MbETV6: 11,649,614–11,895,386, forward strandETV6BCL2L14: 12,049,844–12,211,084, forward strandBCL2L14LRP6: 12,116,025–12,267,044, reverse strandLRP6MANSC1: 12,320,182–12,350,483, reverse strandMANSC1BORCS5: 12,357,057–12,482,332, forward strandBORCS5DUSP16: 12,473,282–12,563,147, reverse strandDUSP16CREBL2: 12,611,812–12,645,375, forward strandCREBL2GPR19: 12,660,047–12,715,990, reverse strandGPR19CDKN1B: 12,685,498–12,722,373, forward strandCDKN1BDiagram of LRP6: 23 exons on the reverse strand of chromosome 12Exon 20: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 16: 2 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 23: 12,116,025–12,121,420, 5,396 basesExon 22: 12,124,565–12,124,662, 98 basesExon 21: 12,125,296–12,125,432, 137 basesExon 20: 12,126,691–12,126,921, 231 basesExon 19: 12,130,783–12,130,893, 111 basesExon 18: 12,131,821–12,132,057, 237 basesExon 17: 12,135,175–12,135,300, 126 basesExon 16: 12,138,325–12,138,534, 210 basesExon 15: 12,147,366–12,147,556, 191 basesExon 14: 12,148,942–12,149,153, 212 basesExon 13: 12,150,836–12,151,038, 203 basesExon 12: 12,158,829–12,159,155, 327 basesExon 11: 12,159,780–12,159,964, 185 basesExon 10: 12,162,193–12,162,419, 227 basesExon 9: 12,164,273–12,164,562, 290 basesExon 8: 12,165,079–12,165,295, 217 basesExon 7: 12,179,810–12,179,981, 172 basesExon 6: 12,181,043–12,181,439, 397 basesExon 5: 12,183,980–12,184,111, 132 basesExon 4: 12,186,923–12,187,119, 197 basesExon 3: 12,203,203–12,203,400, 198 basesExon 2: 12,244,262–12,244,655, 394 basesExon 1: 12,266,681–12,267,044, 364 bases23201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.3 kb of the gene's 151 kb; 4,842 of those bases code for the protein.

How a genome test reads LRP6

17

positions in LRP6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 151 kb of LRP6, introns included, not only the 10.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LRP6 gene: LDL receptor related protein 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/lrp6

Vancouver

Dante Labs. LRP6 gene: LDL receptor related protein 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lrp6

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