Gene
GREM2
gremlin 2, DAN family BMP antagonist
- HGNC 17655↗(opens in a new tab)
- Ensembl gene ENSG00000180875↗(opens in a new tab)
- NCBI Gene 64388↗(opens in a new tab)
Summary
- Cytogenetic location
- 1q43
- Coordinates
- Chromosome 1: 240,489,573–240,612,155 (GRCh38)
- Exons
- 2 exons across 122.6 kb
- Protein
- 168 amino acids
- Also known as
- Prdc, FLJ21195, CKTSF1B2, DAND3
- MANE Select transcript
- ENST00000318160.5NM_022469.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How GREM2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.2 kb of the gene's 122.6 kb; 507 of those bases code for the protein.
Traits linked to GREM2
The Human Phenotype Ontology lists these as features of the rare conditions GREM2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Failure of development of more than six teeth
- Absence of a tooth
- Chewing difficulties
- Absence of premolar
- Absence of six year molar
- Absence of upper lateral incisor
- Absent central incisor
- Bad bite
Show 16 more traits
- Decreased length of dental roots
- Decreased size of tooth
- Delayed eruption of permanent teeth
- Delayed eruption of teeth
- Widely spaced teeth
- Abnormality of canine
- Abnormality of dental shape
- Abnormality of shape of baby molar
- Absence of lower premolar
- Cleft of the mouth
- Decreased size of teeth
- Outward turned lips
- Peg-shaped maxillary lateral incisors
- Short face
- Taurodontia
- Thin dental enamel
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). GREM2 gene: gremlin 2, DAN family BMP antagonist. Retrieved 16 October 2026, from https://dantelabs.com/genes/grem2
Dante Labs. GREM2 gene: gremlin 2, DAN family BMP antagonist [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/grem2
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