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Gene

SCAPER

S-phase cyclin A associated protein in the ER

Summary

Cytogenetic location
15q24.3
Coordinates
Chromosome 15: 76,347,904–76,905,340 (GRCh38)
Exons
32 exons across 557.4 kb
Protein
1,400 amino acids
Also known as
Zfp291
Previous symbols
ZNF291
MANE Select transcript
ENST00000563290.6NM_020843.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong

    How SCAPER is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 15, with a bracket where SCAPER sits. SCAPER and 11 genes near it on chromosome 15, from 75,790,467 to 77,462,777.Chromosome 1515q24.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.375.8 Mb76 Mb76.2 Mb76.4 Mb76.6 Mb76.8 Mb77 Mb77.2 Mb77.4 MbUBE2Q2: 75,843,110–75,901,116, forward strandUBE2Q2FBXO22: 75,903,853–75,942,511, forward strandFBXO22NRG4: 75,935,192–76,059,800, reverse strandNRG4TMEM266: 76,059,916–76,229,121, forward strandTMEM266ETFA: 76,188,201–76,311,730, reverse strandETFAISL2: 76,336,724–76,342,475, forward strandISL2SCAPER: 76,347,904–76,905,340, reverse strandSCAPERRCN2: 76,931,649–76,954,393, forward strandRCN2PSTPIP1: 76,993,325–77,037,475, forward strandPSTPIP1TSPAN3: 77,041,404–77,083,984, reverse strandTSPAN3PEAK1: 77,100,656–77,420,301, reverse strandPEAK1HMG20A: 77,419,830–77,496,554, forward strandHMG20ADiagram of SCAPER: 32 exons on the reverse strand of chromosome 15Exon 25: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 21: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 32: 76,347,904–76,348,736, 833 basesExon 31: 76,351,237–76,351,288, 52 basesExon 30: 76,353,949–76,354,140, 192 basesExon 29: 76,376,162–76,376,311, 150 basesExon 28: 76,381,378–76,381,615, 238 basesExon 27: 76,404,524–76,404,679, 156 basesExon 26: 76,434,078–76,434,310, 233 basesExon 25: 76,471,212–76,471,335, 124 basesExon 24: 76,504,859–76,504,974, 116 basesExon 23: 76,574,158–76,574,284, 127 basesExon 22: 76,621,764–76,621,829, 66 basesExon 21: 76,665,653–76,665,789, 137 basesExon 20: 76,701,758–76,701,865, 108 basesExon 19: 76,702,850–76,703,002, 153 basesExon 18: 76,705,903–76,705,984, 82 basesExon 17: 76,728,595–76,728,737, 143 basesExon 16: 76,733,229–76,733,384, 156 basesExon 15: 76,753,808–76,753,948, 141 basesExon 14: 76,764,961–76,765,072, 112 basesExon 13: 76,765,337–76,765,454, 118 basesExon 12: 76,765,563–76,765,638, 76 basesExon 11: 76,766,918–76,767,088, 171 basesExon 10: 76,771,742–76,771,954, 213 basesExon 9: 76,774,855–76,775,117, 263 basesExon 8: 76,795,280–76,795,440, 161 basesExon 7: 76,800,248–76,800,364, 117 basesExon 6: 76,804,533–76,804,633, 101 basesExon 5: 76,841,734–76,841,931, 198 basesExon 4: 76,857,809–76,857,879, 71 basesExon 3: 76,862,416–76,862,533, 118 basesExon 2: 76,883,812–76,883,876, 65 basesExon 1: 76,905,299–76,905,340, 42 bases322015′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5 kb of the gene's 557.4 kb; 4,203 of those bases code for the protein.

    How a genome test reads SCAPER

    11

    positions in SCAPER where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 557.4 kb of SCAPER, introns included, not only the 5 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). SCAPER gene: S-phase cyclin A associated protein in the ER. Retrieved 16 October 2026, from https://dantelabs.com/genes/scaper

    Vancouver

    Dante Labs. SCAPER gene: S-phase cyclin A associated protein in the ER [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/scaper

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