Skip to content
Use your HSA or FSA funds

Gene

PRKACA

protein kinase cAMP-activated catalytic subunit alpha

Summary

Cytogenetic location
19p13.12
Coordinates
Chromosome 19: 14,091,688–14,117,762 (GRCh38)
Exons
10 exons across 26.1 kb
Protein
351 amino acids
Also known as
PKACa
MANE Select transcript
ENST00000308677.9NM_002730.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PRKACA yet. The test sequences your whole genome, so your data includes it all the same.

How PRKACA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where PRKACA sits. PRKACA and 30 genes near it on chromosome 19, from 13,604,725 to 14,604,724.Chromosome 1919p13.12p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4313.8 Mb14 Mb14.2 Mb14.4 Mb14.6 MbCACNA1A: 13,206,442–13,624,489, reverse strandCACNA1AYJU2B: 13,731,746–13,763,298, forward strandYJU2BMRI1: 13,764,498–13,774,282, forward strandMRI1C19orf53: 13,774,439–13,778,773, forward strandC19orf53ZSWIM4: 13,795,395–13,832,254, forward strandZSWIM4NANOS3: 13,862,063–13,880,757, forward strandNANOS3BRME1: 13,882,343–13,906,572, reverse strandBRME1CC2D1A: 13,906,160–13,930,884, forward strandCC2D1APODNL1: 13,931,183–13,953,392, reverse strandPODNL1DCAF15: 13,952,459–13,961,449, forward strandDCAF15RFX1: 13,961,529–14,007,084, reverse strandRFX1RLN3: 14,028,148–14,031,552, forward strandRLN3IL27RA: 14,031,644–14,053,223, forward strandIL27RAPALM3: 14,053,363–14,062,149, reverse strandMISP3: 14,072,108–14,075,062, forward strandC19orf67: 14,081,624–14,085,875, reverse strandC19orf67SAMD1: 14,086,762–14,091,036, reverse strandSAMD1PRKACA: 14,091,688–14,117,762, reverse strandPRKACASMIM46: 14,112,324–14,112,476, reverse strandSMIM46ASF1B: 14,119,512–14,136,622, reverse strandADGRL1: 14,147,743–14,206,852, reverse strandADGRL1ADGRE5: 14,380,501–14,408,729, forward strandADGRE5DDX39A: 14,408,798–14,419,385, reverse strandDDX39APKN1: 14,433,053–14,471,872, forward strandPKN1PTGER1: 14,472,466–14,477,272, reverse strandPTGER1GIPC1: 14,477,759–14,496,164, reverse strandGIPC1DNAJB1: 14,513,789–14,560,391, reverse strandDNAJB1TECR: 14,517,085–14,565,988, forward strandTECRNDUFB7: 14,566,078–14,572,079, reverse strandNDUFB7CLEC17A: 14,583,084–14,612,035, forward strandCLEC17AADGRE3: 14,599,080–14,690,027, reverse strandADGRE3Diagram of PRKACA: 10 exons on the reverse strand of chromosome 19Exon 7: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 10: 14,091,688–14,093,237, 1,550 basesExon 9: 14,093,628–14,093,792, 165 basesExon 8: 14,097,361–14,097,483, 123 basesExon 7: 14,097,579–14,097,674, 96 basesExon 6: 14,097,764–14,097,890, 127 basesExon 5: 14,100,826–14,100,908, 83 basesExon 4: 14,102,816–14,102,914, 99 basesExon 3: 14,106,760–14,106,888, 129 basesExon 2: 14,107,348–14,107,409, 62 basesExon 1: 14,117,502–14,117,762, 261 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 26.1 kb; 1,056 of those bases code for the protein.

How a genome test reads PRKACA

2

positions in PRKACA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.1 kb of PRKACA, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PRKACA gene: protein kinase cAMP-activated catalytic subunit alpha. Retrieved 16 October 2026, from https://dantelabs.com/genes/prkaca

Vancouver

Dante Labs. PRKACA gene: protein kinase cAMP-activated catalytic subunit alpha [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prkaca

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test