Gene
TRIM32
tripartite motif containing 32
- HGNC 16380(opens in a new tab)
- Ensembl gene ENSG00000119401(opens in a new tab)
- NCBI Gene 22954(opens in a new tab)
Summary
- Cytogenetic location
- 9q33.1
- Coordinates
- Chromosome 9: 116,687,305–116,701,299 (GRCh38)
- Exons
- 2 exons across 14 kb
- Protein
- 653 amino acids
- Inheritance
- Autosomal recessive
- Also known as
- HT2A, TATIP, BBS11
- Previous symbols
- LGMD2H
- MANE Select transcript
- ENST00000450136.2NM_012210.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
Bardet-Biedl and Alström Syndromes
- Bardet-Biedl syndromeAutosomal recessive
A recessive ciliopathy caused by variants in more than 20 genes (most often BBS1 and BBS10) that causes retinal dystrophy, obesity, extra fingers or toes, kidney anomalies and learning difficulties.
- 1 GenCC submitter rates it definitive or strong
What knowing changes
Diagnosis allows eye, kidney and diabetes surveillance, and setmelanotide is an approved treatment for obesity in Bardet-Biedl syndrome.
Limb-Girdle Muscular Dystrophy
Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.
- ClinGen rates the link definitive
- 5 GenCC submitters rate it definitive or strong
Inheritance
- Autosomal recessive
- It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.
How TRIM32 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.7 kb of the gene's 14 kb; 1,962 of those bases code for the protein.
How a genome test reads TRIM32
64
positions in TRIM32 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 14 kb of TRIM32, introns included, not only the 3.7 kb of exons.
Traits linked to TRIM32
The Human Phenotype Ontology lists these as features of the rare conditions TRIM32 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). TRIM32 gene: tripartite motif containing 32. Retrieved 16 October 2026, from https://dantelabs.com/genes/trim32
Dante Labs. TRIM32 gene: tripartite motif containing 32 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/trim32
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