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Gene

REV3L

REV3 like, DNA directed polymerase zeta catalytic subunit

Summary

Cytogenetic location
6q21
Coordinates
Chromosome 6: 111,299,033–111,483,218 (GRCh38)
Exons
32 exons across 184.2 kb
Protein
3,130 amino acids
Inheritance
Autosomal dominant
Also known as
POLZ, REV3
MANE Select transcript
ENST00000368802.8NM_001372078.1
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Mobius SyndromeAutosomal dominant

      Moebius syndrome is a very rare congenital cranial dysinnervation disorder characterized by complete or incomplete facial paralysis in association with bilateral palsy of the abducens nerve causing impairment of ocular abduction. The syndrome also includes various other congenital anomalies.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How REV3L is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where REV3L sits. REV3L and 7 genes near it on chromosome 6, from 110,891,126 to 111,891,125.Chromosome 66q21p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27111 Mb111.2 Mb111.4 Mb111.6 Mb111.8 MbAMD1: 110,874,770–110,898,879, forward strandAMD1GTF3C6: 110,958,477–110,968,586, forward strandGTF3C6RPF2: 110,982,015–111,028,264, forward strandRPF2SLC16A10: 111,087,445–111,258,090, forward strandSLC16A10SLC60A2: 111,259,327–111,445,354, forward strandSLC60A2REV3L: 111,299,033–111,483,218, reverse strandREV3LTRAF3IP2: 111,555,381–111,606,910, reverse strandTRAF3IP2FYN: 111,660,332–111,873,479, reverse strandFYNDiagram of REV3L: 32 exons on the reverse strand of chromosome 6Exon 32: 111,299,033–111,300,156, 1,124 basesExon 31: 111,307,361–111,307,570, 210 basesExon 30: 111,309,853–111,310,099, 247 basesExon 29: 111,311,069–111,311,259, 191 basesExon 28: 111,313,352–111,313,489, 138 basesExon 27: 111,315,267–111,315,381, 115 basesExon 26: 111,322,569–111,322,678, 110 basesExon 25: 111,329,532–111,329,738, 207 basesExon 24: 111,331,676–111,331,784, 109 basesExon 23: 111,333,123–111,333,367, 245 basesExon 22: 111,335,469–111,335,610, 142 basesExon 21: 111,343,925–111,344,043, 119 basesExon 20: 111,349,218–111,349,336, 119 basesExon 19: 111,351,676–111,351,791, 116 basesExon 18: 111,357,014–111,357,125, 112 basesExon 17: 111,358,822–111,359,014, 193 basesExon 16: 111,363,853–111,363,978, 126 basesExon 15: 111,365,265–111,365,344, 80 basesExon 14: 111,367,115–111,368,028, 914 basesExon 13: 111,372,596–111,376,757, 4,162 basesExon 12: 111,377,701–111,377,843, 143 basesExon 11: 111,379,982–111,380,219, 238 basesExon 10: 111,381,325–111,381,444, 120 basesExon 9: 111,387,765–111,387,913, 149 basesExon 8: 111,388,001–111,388,085, 85 basesExon 7: 111,389,106–111,389,210, 105 basesExon 6: 111,390,086–111,390,180, 95 basesExon 5: 111,392,876–111,392,972, 97 basesExon 4: 111,405,470–111,405,630, 161 basesExon 3: 111,411,480–111,411,554, 75 basesExon 2: 111,416,283–111,416,472, 190 basesExon 1: 111,482,750–111,483,218, 469 bases323025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.7 kb of the gene's 184.2 kb; 9,393 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). REV3L gene: REV3 like, DNA directed polymerase zeta catalytic subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/rev3l

Vancouver

Dante Labs. REV3L gene: REV3 like, DNA directed polymerase zeta catalytic subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rev3l

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