Gene
TGFA
transforming growth factor alpha
- HGNC 11765↗(opens in a new tab)
- Ensembl gene ENSG00000163235↗(opens in a new tab)
- NCBI Gene 7039↗(opens in a new tab)
Summary
- Cytogenetic location
- 2p13.3
- Coordinates
- Chromosome 2: 70,447,284–70,553,826 (GRCh38)
- Exons
- 6 exons across 106.5 kb
- Protein
- 160 amino acids
- MANE Select transcript
- ENST00000295400.11NM_003236.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How TGFA is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.1 kb of the gene's 106.5 kb; 483 of those bases code for the protein.
Traits linked to TGFA
The Human Phenotype Ontology lists these as features of the rare conditions TGFA can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Failure of development of more than six teeth
- Chewing difficulties
- Absence of premolar
- Absence of six year molar
- Absence of upper lateral incisor
- Absent central incisor
- Bad bite
- Decreased length of dental roots
Show 15 more traits
- Decreased size of tooth
- Delayed eruption of permanent teeth
- Delayed eruption of teeth
- Widely spaced teeth
- Abnormality of canine
- Abnormality of dental shape
- Abnormality of shape of baby molar
- Absence of lower premolar
- Cleft of the mouth
- Decreased size of teeth
- Outward turned lips
- Peg-shaped maxillary lateral incisors
- Short face
- Taurodontia
- Thin dental enamel
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). TGFA gene: transforming growth factor alpha. Retrieved 16 October 2026, from https://dantelabs.com/genes/tgfa
Dante Labs. TGFA gene: transforming growth factor alpha [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tgfa
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