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Gene

SMOC2

SPARC related modular calcium binding 2

Summary

Cytogenetic location
6q27
Coordinates
Chromosome 6: 168,441,184–168,667,992 (GRCh38)
Exons
13 exons across 226.8 kb
Protein
446 amino acids
Also known as
SMAP2
MANE Select transcript
ENST00000356284.7NM_001166412.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dentinogenesis Imperfecta

    • Dentin Dysplasia

      Inherited defects of dentin that cause short or malformed roots, abnormal pulp chambers and early tooth loss, with type II caused by DSPP variants on the same spectrum as dentinogenesis imperfecta.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing can support early dental monitoring and planning to protect affected teeth.

How SMOC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where SMOC2 sits. SMOC2 and 2 genes near it on chromosome 6, from 168,054,588 to 169,054,587.Chromosome 66q27p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27168.2 Mb168.4 Mb168.6 Mb168.8 Mb169 MbFRMD1: 168,053,095–168,101,511, reverse strandFRMD1DACT2: 168,292,830–168,319,783, reverse strandDACT2SMOC2: 168,441,184–168,667,992, forward strandSMOC2Diagram of SMOC2: 13 exons on the forward strand of chromosome 6Exon 1: 168,441,184–168,441,454, 271 basesExon 2: 168,509,915–168,510,086, 172 basesExon 3: 168,526,346–168,526,452, 107 basesExon 4: 168,527,628–168,527,727, 100 basesExon 5: 168,543,625–168,543,672, 48 basesExon 6: 168,547,119–168,547,169, 51 basesExon 7: 168,549,129–168,549,203, 75 basesExon 8: 168,598,818–168,599,004, 187 basesExon 9: 168,608,157–168,608,239, 83 basesExon 10: 168,650,681–168,650,783, 103 basesExon 11: 168,652,954–168,653,228, 275 basesExon 12: 168,664,074–168,664,111, 38 basesExon 13: 168,666,421–168,667,992, 1,572 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 226.8 kb; 1,341 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SMOC2 gene: SPARC related modular calcium binding 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/smoc2

Vancouver

Dante Labs. SMOC2 gene: SPARC related modular calcium binding 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/smoc2

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