Gene
WDPCP
WD repeat containing planar cell polarity effector
- HGNC 28027↗(opens in a new tab)
- Ensembl gene ENSG00000143951↗(opens in a new tab)
- NCBI Gene 51057↗(opens in a new tab)
Summary
- Cytogenetic location
- 2p15
- Coordinates
- Chromosome 2: 63,119,559–63,588,477 (GRCh38)
- Exons
- 18 exons across 468.9 kb
- Protein
- 746 amino acids
- Inheritance
- Autosomal recessive
- Also known as
- hFrtz, fritz, BBS15, CPLANE5
- Previous symbols
- C2orf86
- MANE Select transcript
- ENST00000272321.12NM_015910.7
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Read WDPCP, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated report relevant to this gene
Bardet-Biedl and Alström Syndromes
- Bardet-Biedl syndromeAutosomal recessive
A recessive ciliopathy caused by variants in more than 20 genes (most often BBS1 and BBS10) that causes retinal dystrophy, obesity, extra fingers or toes, kidney anomalies and learning difficulties.
- 2 GenCC submitters rate it definitive or strong
What knowing changes
Diagnosis allows eye, kidney and diabetes surveillance, and setmelanotide is an approved treatment for obesity in Bardet-Biedl syndrome.
Inheritance
- Autosomal recessive
- It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.
How WDPCP is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.9 kb of the gene's 468.9 kb; 2,241 of those bases code for the protein.
How a genome test reads WDPCP
43
positions in WDPCP where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 468.9 kb of WDPCP, introns included, not only the 4.9 kb of exons.
Genes linked to the same conditions
- ARL6ARF like GTPase 6Shares 1 condition
- BBIP1BBSome interacting protein 1Shares 1 condition
- BBS1Bardet-Biedl syndrome 1Shares 1 condition
- BBS10Bardet-Biedl syndrome 10Shares 1 condition
- BBS12Bardet-Biedl syndrome 12Shares 1 condition
- BBS2Bardet-Biedl syndrome 2Shares 1 condition
- BBS4Bardet-Biedl syndrome 4Shares 1 condition
- BBS5Bardet-Biedl syndrome 5Shares 1 condition
- BBS7Bardet-Biedl syndrome 7Shares 1 condition
- BBS9Bardet-Biedl syndrome 9Shares 1 condition
- CEP290centrosomal protein 290Shares 1 condition
- CFAP418cilia and flagella associated protein 418Shares 1 condition
Traits linked to WDPCP
The Human Phenotype Ontology lists these as features of the rare conditions WDPCP can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). WDPCP gene: WD repeat containing planar cell polarity effector. Retrieved 17 October 2026, from https://dantelabs.com/genes/wdpcp
Dante Labs. WDPCP gene: WD repeat containing planar cell polarity effector [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wdpcp
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks