Traits

Traits linked to WT1

WT1 transcription factor

The Human Phenotype Ontology links 189 traits to WT1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	Hvor ofte den forekommer
Ambiguous genitalia in males	Alltid
Diffuse mesangial sclerosis	Alltid
Double uterus	Alltid
Double vagina	Alltid
Enlarged kidney	Alltid
Focal segmental glomerulosclerosis	Alltid
Glomerulopathy	Alltid
Gonadal dysgenesis	Alltid
Male pseudohermaphroditism	Alltid
Nephrotic syndrome	Alltid
Ovarian gonadoblastoma	Alltid
Primary amenorrhea	Alltid
Stage 5 chronic kidney disease	Alltid
Abnormal fallopian tube morphology	Svært ofte (80–99 %)
Abnormal internal genitalia	Svært ofte (80–99 %)
Abnormal labia morphology	Svært ofte (80–99 %)
Abnormal scrotum morphology	Svært ofte (80–99 %)
Abnormal sex determination	Svært ofte (80–99 %)
Abnormal vagina morphology	Svært ofte (80–99 %)
Abnormally closed or absent vagina	Svært ofte (80–99 %)
Absent sperm in semen	Svært ofte (80–99 %)
Ambiguous external genitalia	Svært ofte (80–99 %)
Decreased fertility in females	Svært ofte (80–99 %)
Decreased testicular size	Svært ofte (80–99 %)
Dysplastic testis	Svært ofte (80–99 %)
Enlarged clitoris	Svært ofte (80–99 %)
Female external genitalia in individual with 46,XY karyotype	Svært ofte (80–99 %)
Gonadal dysgenesis with female appearance, male	Svært ofte (80–99 %)
Hypospadias	Svært ofte (80–99 %)
Kidney damage	Svært ofte (80–99 %)
Male infertility	Svært ofte (80–99 %)
Nephroblastoma	Svært ofte (80–99 %)
Polycystic ovaries	Svært ofte (80–99 %)
Short penis	Svært ofte (80–99 %)
Streak ovary	Svært ofte (80–99 %)
Underdeveloped penis	Svært ofte (80–99 %)
Underdeveloped vagina	Svært ofte (80–99 %)
Urogenital sinus anomaly	Svært ofte (80–99 %)
Vanishing testis	Svært ofte (80–99 %)
Chronic kidney disease	Ofte (30–79 %)
Displacement of the urethral meatus	Ofte (30–79 %)
Gonadoblastoma	Ofte (30–79 %)
Hydrometrocolpos	Ofte (30–79 %)
Renal failure	Ofte (30–79 %)
Undescended testes	Ofte (30–79 %)
Abnormal kidney location	Noen ganger (5–29 %)
Abnormal uterus morphology	Noen ganger (5–29 %)
Abnormality of the uterus	Noen ganger (5–29 %)
Blind vagina	Noen ganger (5–29 %)
Crossed fused renal ectopia	Noen ganger (5–29 %)
Ectopic testis	Noen ganger (5–29 %)
Heart shaped uterus	Noen ganger (5–29 %)
Horseshoe kidney	Noen ganger (5–29 %)
Minimal change glomerulonephritis	Noen ganger (5–29 %)
Ovarian cancer	Noen ganger (5–29 %)
Testicular cancer	Noen ganger (5–29 %)
Testicular gonadoblastoma	Noen ganger (5–29 %)
Varicocele	Noen ganger (5–29 %)
Atypical appearance of female genitals	Ikke registrert
Gonadal tissue inappropriate for external genitalia or chromosomal sex	Ikke registrert
True hermaphroditism	Ikke registrert

Abnormality of the cardiovascular system

Trait	Hvor ofte den forekommer
Retinal vascular tortuosity	Alltid
Swollen lymph nodes	Svært ofte (80–99 %)
High blood pressure	Ofte (30–79 %)
Swollen lymph nodes in center of chest	Ofte (30–79 %)
Underdeveloped left heart	Ofte (30–79 %)
Abnormality of the spleen	Noen ganger (5–29 %)
Accessory spleen	Noen ganger (5–29 %)
All organs on wrong side of body	Noen ganger (5–29 %)
An opening in the wall separating the top two chambers of the heart	Noen ganger (5–29 %)
Anomalous pulmonary venous return	Noen ganger (5–29 %)
Aortic valve has two leaflets rather than three	Noen ganger (5–29 %)
Cardiac total anomalous pulmonary venous connection	Noen ganger (5–29 %)
Common atrium	Noen ganger (5–29 %)
Conotruncal defect	Noen ganger (5–29 %)
Heart tip and four chambers point towards right side of body	Noen ganger (5–29 %)
Hole in heart wall separating two lower heart chambers	Noen ganger (5–29 %)
Narrowing of aorta	Noen ganger (5–29 %)
Narrowing of aortic valve	Noen ganger (5–29 %)
Partial anomalous pulmonary venous return	Noen ganger (5–29 %)
Patent ductus arteriosus	Noen ganger (5–29 %)
Persistent left superior vena cava	Noen ganger (5–29 %)
Right aortic arch	Noen ganger (5–29 %)
Scimitar anomaly	Noen ganger (5–29 %)
Tetralogy of Fallot	Noen ganger (5–29 %)
Transposition of the great arteries	Noen ganger (5–29 %)
Abnormal cardiovascular system morphology	Sjelden (1–4%)

Abnormality of the eye

Trait	Hvor ofte den forekommer
Absent iris	Alltid
Anterior subcapsular cataract	Alltid
Chorioretinal hypopigmentation	Alltid
Damage to outer layer of the cornea of the eye	Alltid
Displaced pupil	Alltid
Drooping of both upper eyelids	Alltid
Hypoplasia of the fovea	Alltid
Outward facing eye ball	Alltid
Underdeveloped iris	Alltid
Absent/small iris	Svært ofte (80–99 %)
Involuntary, rapid, rhythmic eye movements	Svært ofte (80–99 %)
Clouding of the lens of the eye	Ofte (30–79 %)
Cross-eyed	Ofte (30–79 %)
Drooping upper eyelid	Ofte (30–79 %)
Glaucoma	Ofte (30–79 %)
New blood vessel formation in cornea	Ofte (30–79 %)
Visual impairment	Ofte (30–79 %)
Ectopia lentis	Noen ganger (5–29 %)
Macular agenesis	Noen ganger (5–29 %)
Opacification of the corneal stroma	Ikke registrert
Optic nerve hypoplasia	Ikke registrert

Abnormality of the digestive system

Trait	Hvor ofte den forekommer
Abdominal bloating	Svært ofte (80–99 %)
Abdominal mass	Svært ofte (80–99 %)
Abdominal pain	Svært ofte (80–99 %)
Abnormal peritoneum morphology	Svært ofte (80–99 %)
Duplication of renal pelvis	Ofte (30–79 %)
Enlarged liver	Ofte (30–79 %)
Ileus	Ofte (30–79 %)
Nausea and vomiting	Ofte (30–79 %)
Accumulation of fluid in the abdomen	Noen ganger (5–29 %)
Cancer of the pancreas	Noen ganger (5–29 %)
Liver cancer	Noen ganger (5–29 %)
Peritonitis	Sjelden (1–4%)

Abnormality of the endocrine system

Trait	Hvor ofte den forekommer
Decreased serum estradiol	Svært ofte (80–99 %)
Decreased serum testosterone level	Svært ofte (80–99 %)
Elevated circulating follicle stimulating hormone level	Svært ofte (80–99 %)
Elevated circulating luteinizing hormone level	Svært ofte (80–99 %)
Hypergonadotropic hypogonadism	Svært ofte (80–99 %)
Hypogonadotropic hypogonadism	Svært ofte (80–99 %)
Increased circulating gonadotropin level	Svært ofte (80–99 %)
Delayed puberty	Ofte (30–79 %)
Absence of secondary sex characteristics	Noen ganger (5–29 %)
Adrenal insufficiency	Noen ganger (5–29 %)
Primary gonadal insufficiency	Noen ganger (5–29 %)

Laboratory abnormality

Trait	Hvor ofte den forekommer
High urine protein levels	Alltid
Fluid retention	Svært ofte (80–99 %)
Bloody urine	Ofte (30–79 %)
Fever	Noen ganger (5–29 %)
Foamy urine	Noen ganger (5–29 %)
High blood calcium levels	Noen ganger (5–29 %)
Low albumin	Noen ganger (5–29 %)
Small amount of blood in urine	Noen ganger (5–29 %)
Glucose intolerance	Ikke registrert
Increased proinsulin:insulin ratio	Ikke registrert

Abnormality of the respiratory system

Trait	Hvor ofte den forekommer
Neonatal respiratory distress	Alltid
Absent/small lungs	Svært ofte (80–99 %)
Abnormal lung lobation	Ofte (30–79 %)
Poorly developed lungs	Ofte (30–79 %)
Pulmonary sequestration	Ofte (30–79 %)
Congenital alveolar dysplasia	Noen ganger (5–29 %)
Lung cancer	Noen ganger (5–29 %)
Respiratory tract infection	Noen ganger (5–29 %)
Breathing difficulty	Sjelden (1–4%)

Abnormality of the musculoskeletal system

Trait	Hvor ofte den forekommer
Posterolateral diaphragmatic hernia	Alltid
Congenital diaphragmatic hernia	Svært ofte (80–99 %)
Osteoporosis	Svært ofte (80–99 %)
Aplasia of the left hemidiaphragm	Ofte (30–79 %)
Aplasia of the right hemidiaphragm	Ofte (30–79 %)
Delayed bone maturation	Noen ganger (5–29 %)
Diaphragmatic eventration	Noen ganger (5–29 %)
Scoliosis	Noen ganger (5–29 %)

Abnormality of the nervous system

Trait	Hvor ofte den forekommer
Intellectual disability	Ofte (30–79 %)
Dysfunction of lateral corticospinal tracts	Noen ganger (5–29 %)
Headache	Noen ganger (5–29 %)
Irritability	Noen ganger (5–29 %)
Tumors of the central nervous system	Noen ganger (5–29 %)
Abnormality of the nervous system	Sjelden (1–4%)
More grooves in brain	Ikke registrert
Underdevelopment of part of brain called corpus callosum	Ikke registrert

Abnormality of head or neck

Trait	Hvor ofte den forekommer
Eye folds	Alltid
Wider-than-typical soft spot of skull	Alltid
Abnormally small head	Ofte (30–79 %)
Drooping lower lip	Ofte (30–79 %)
Little lower jaw	Ofte (30–79 %)
Periorbital edema	Ofte (30–79 %)

Growth abnormality

Trait	Hvor ofte den forekommer
Short stature	Ofte (30–79 %)
Weight loss	Ofte (30–79 %)
Obesity	Noen ganger (5–29 %)
Wasting syndrome	Noen ganger (5–29 %)

Abnormal tissue mass

Trait	Hvor ofte den forekommer
Abnormal tissue mass	Svært ofte (80–99 %)
Cancer of connective tissue	Svært ofte (80–99 %)
Malignant mesothelioma	Ikke registrert

Abnormality of blood and blood-forming tissues

Trait	Hvor ofte den forekommer
Increased red blood cells	Noen ganger (5–29 %)
Low number of red blood cells or hemoglobin	Noen ganger (5–29 %)
Reduced von Willebrand factor activity	Noen ganger (5–29 %)

Abnormality of the integument

Trait	Hvor ofte den forekommer
Limited armpit hair	Svært ofte (80–99 %)
Sparse pubic hair	Svært ofte (80–99 %)

Abnormality of limbs

Trait	Hvor ofte den forekommer
Asymmetric overgrowth	Noen ganger (5–29 %)

Abnormality of prenatal development or birth

Trait	Hvor ofte den forekommer
Only one artery in umbilical cord instead of two	Noen ganger (5–29 %)

Abnormality of the breast

Trait	Hvor ofte den forekommer
Enlarged male breast	Svært ofte (80–99 %)

Abnormality of the ear

Trait	Hvor ofte den forekommer
Hearing abnormality	Ofte (30–79 %)

Constitutional symptom

Trait	Hvor ofte den forekommer
Malaise	Noen ganger (5–29 %)

Hvor ofte dette forekommer hos personer med en av genets tilstander, oppgitt som den hyppigste forekomsten blant dem, slik Human Phenotype Ontology registrerer den. Disse sidene beskriver egenskaper og forskningen bak dem. De er ikke en diagnose, og om symptomer bør du spørre lege eller genetisk rådgiver.

Slik er informasjonen samlet

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WT1 and how often each is seen. Find out more at hpo.jax.org.

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