Trait

Central sleep apnea

Sleep apnea results from a temporary loss of the central drive to the muscles responsible for breathing.

Also called: Central sleep apnoea
Body system: Abnormality of the nervous system

This page as data

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library(jsonlite)

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page <- fromJSON(url)
page$trait$name

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25 genes linked to Central sleep apnea

Changes in these genes cause rare conditions in which Central sleep apnea is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CACNA1Ccalcium voltage-gated channel subunit alpha1 C	Always	In 1 condition
DOT1LDOT1 like histone lysine methyltransferase	Always	In 1 condition
FBXO28F-box protein 28	Always	In 1 condition
FEM1Bfem-1 homolog B	Always	In 1 condition
FLVCR1FLVCR choline and heme transporter 1	Always	In 1 condition
PLCB4phospholipase C beta 4	Always	In 1 condition
ASCL1achaete-scute family bHLH transcription factor 1	Very often (80–99%)	In 1 condition
KCNK3potassium two pore domain channel subfamily K member 3	Very often (80–99%)	In 1 condition
PHOX2Bpaired like homeobox 2B	Very often (80–99%)	In 1 condition
RETret proto-oncogene	Very often (80–99%)	In 1 condition
CCDC47coiled-coil domain containing 47	Often (30–79%)	In 1 condition
COQ2coenzyme Q2, polyprenyltransferase	Often (30–79%)	In 2 conditions
FGFR3fibroblast growth factor receptor 3	Often (30–79%)	In 1 condition
NADK2NAD kinase 2, mitochondrial	Often (30–79%)	In 1 condition
ASCC3activating signal cointegrator 1 complex subunit 3	Sometimes (5–29%)	In 1 condition
CACNA1Icalcium voltage-gated channel subunit alpha1 I	Sometimes (5–29%)	In 1 condition
CDK13cyclin dependent kinase 13	Sometimes (5–29%)	In 1 condition
DKK1dickkopf Wnt signaling pathway inhibitor 1	Sometimes (5–29%)	In 1 condition
LRPPRCleucine rich pentatricopeptide repeat containing	Sometimes (5–29%)	In 1 condition
MAGEL2MAGE family member L2	Sometimes (5–29%)	In 1 condition
NGLY1N-glycanase 1	Sometimes (5–29%)	In 1 condition
PIGTphosphatidylinositol glycan anchor biosynthesis class T	Sometimes (5–29%)	In 1 condition
PRPS1phosphoribosyl pyrophosphate synthetase 1	Sometimes (5–29%)	In 1 condition
SIM1SIM bHLH transcription factor 1	Sometimes (5–29%)	In 1 condition
USP7ubiquitin specific peptidase 7	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Pauses in breathing while sleeping

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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