Trait
Temperature instability
Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature.
Summary
- Also called
- Body temperature instability
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test42 genes linked to Temperature instability
Changes in these genes cause rare conditions in which Temperature instability is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HIVEP2HIVEP zinc finger 2 | Always | In 1 condition |
| SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor | Always | In 1 condition |
| SLC18A2solute carrier family 18 member A2 | Always | In 1 condition |
| SLC31A1solute carrier family 31 member 1 | Always | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 4 conditions |
| CRIPTOcripto, EGF-CFC family member | Often (30–79%) | In 4 conditions |
| DISP1dispatched RND transporter family member 1 | Often (30–79%) | In 4 conditions |
| DLL1delta like canonical Notch ligand 1 | Often (30–79%) | In 4 conditions |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 4 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 2 conditions |
| FOXH1forkhead box H1 | Often (30–79%) | In 4 conditions |
| GAS1growth arrest specific 1 | Often (30–79%) | In 4 conditions |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 4 conditions |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 2 conditions |
| MYO1Hmyosin IH | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 4 conditions |
| PLCH1phospholipase C eta 1 | Often (30–79%) | In 1 condition |
| PTCH1patched 1 | Often (30–79%) | In 4 conditions |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 4 conditions |
| SIX3SIX homeobox 3 | Often (30–79%) | In 4 conditions |
| SLC25A19solute carrier family 25 member 19 | Often (30–79%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| SPRsepiapterin reductase | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 2 conditions |
| STILSTIL centriolar assembly protein | Often (30–79%) | In 4 conditions |
| TGIF1TGFB induced factor homeobox 1 | Often (30–79%) | In 4 conditions |
| ZIC2Zic family zinc finger 2 | Often (30–79%) | In 4 conditions |
| ALG11ALG11 alpha-1,2-mannosyltransferase | Sometimes (5–29%) | In 2 conditions |
| FCGR3BFc gamma receptor IIIb | Sometimes (5–29%) | In 1 condition |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Sometimes (5–29%) | In 1 condition |
| LMNB1lamin B1 | Sometimes (5–29%) | In 1 condition |
| MKRN3makorin ring finger protein 3 | Sometimes (5–29%) | In 1 condition |
| NPAP1nuclear pore associated protein 1 | Sometimes (5–29%) | In 1 condition |
| PLA2G6phospholipase A2 group VI | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Sometimes (5–29%) | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Sometimes (5–29%) | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Sometimes (5–29%) | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Sometimes (5–29%) | In 1 condition |
Show 2 more genes
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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