Trait
Central hypothyroidism
A type of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland. Central hypothyroidism is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects.
Summary
- Body system
- Abnormality of the endocrine system
Read the genes linked to Central hypothyroidism, and the rest of your genome, with one test.
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Get my Genome Test39 genes linked to Central hypothyroidism
Changes in these genes cause rare conditions in which Central hypothyroidism is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DMXL2Dmx like 2 | Always | In 2 conditions |
| GLI2GLI family zinc finger 2 | Always | In 5 conditions |
| NINninein | Always | In 1 condition |
| OTX2orthodenticle homeobox 2 | Always | In 1 condition |
| ROBO1roundabout guidance receptor 1 | Always | In 1 condition |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Always | In 1 condition |
| CPEcarboxypeptidase E | Often (30–79%) | In 1 condition |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 4 conditions |
| NDNnecdin, MAGE family member | Often (30–79%) | In 3 conditions |
| NEXMIFneurite extension and migration factor | Often (30–79%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Often (30–79%) | In 3 conditions |
| RPL10ribosomal protein L10 | Often (30–79%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Often (30–79%) | In 3 conditions |
| CDONcell adhesion associated, oncogene regulated | Sometimes (5–29%) | In 4 conditions |
| CRIPTOcripto, EGF-CFC family member | Sometimes (5–29%) | In 4 conditions |
| DISP1dispatched RND transporter family member 1 | Sometimes (5–29%) | In 4 conditions |
| DLL1delta like canonical Notch ligand 1 | Sometimes (5–29%) | In 4 conditions |
| EIF2AK3eukaryotic translation initiation factor 2 alpha kinase 3 | Sometimes (5–29%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Sometimes (5–29%) | In 4 conditions |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 2 conditions |
| FOXH1forkhead box H1 | Sometimes (5–29%) | In 4 conditions |
| GAS1growth arrest specific 1 | Sometimes (5–29%) | In 4 conditions |
| GNAQG protein subunit alpha q | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 1 condition |
| NODALnodal growth differentiation factor | Sometimes (5–29%) | In 4 conditions |
| PLCH1phospholipase C eta 1 | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 4 conditions |
| SHHsonic hedgehog signaling molecule | Sometimes (5–29%) | In 4 conditions |
| SIM1SIM bHLH transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SIX3SIX homeobox 3 | Sometimes (5–29%) | In 4 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Sometimes (5–29%) | In 2 conditions |
| STILSTIL centriolar assembly protein | Sometimes (5–29%) | In 4 conditions |
| TGIF1TGFB induced factor homeobox 1 | Sometimes (5–29%) | In 4 conditions |
| ZIC2Zic family zinc finger 2 | Sometimes (5–29%) | In 4 conditions |
| SETBP1SET binding protein 1 | Rarely (1–4%) | In 1 condition |
| IRS4insulin receptor substrate 4 | Not recorded | In 1 condition |
| KATNIPkatanin interacting protein | Not recorded | In 1 condition |
| TBL1Xtransducin beta like 1 X-linked | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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