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Trait

Premature adrenarche

Onset of adrenarche at an earlier age than usual.

HPO HP:0012412

Summary

Body system
Abnormality of the endocrine system

15 genes linked to Premature adrenarche

Changes in these genes cause rare conditions in which Premature adrenarche is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AMOTL1angiomotin like 1AlwaysIn 1 condition
FEM1Bfem-1 homolog BAlwaysIn 1 condition
KDM6Blysine demethylase 6BAlwaysIn 1 condition
TAF4TATA-box binding protein associated factor 4AlwaysIn 1 condition
CYP11B1cytochrome P450 family 11 subfamily B member 1Often (30–79%)In 1 condition
MAGEL2MAGE family member L2Often (30–79%)In 3 conditions
NDNnecdin, MAGE family memberOften (30–79%)In 3 conditions
OCA2OCA2 melanosomal transmembrane proteinOften (30–79%)In 3 conditions
SNRPNsmall nuclear ribonucleoprotein polypeptide NOften (30–79%)In 3 conditions
USP7ubiquitin specific peptidase 7Often (30–79%)In 1 condition
GRB10growth factor receptor bound protein 10Sometimes (5–29%)In 1 condition
H6PDhexose-6-phosphate dehydrogenase/glucose 1-dehydrogenaseSometimes (5–29%)In 1 condition
HSD11B1hydroxysteroid 11-beta dehydrogenase 1Sometimes (5–29%)In 1 condition
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2Sometimes (5–29%)In 1 condition
SIM1SIM bHLH transcription factor 1Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Early onset of sexual maturation

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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