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Gene

ARHGAP35

Rho GTPase activating protein 35

Summary

Cytogenetic location
19q13.32
Coordinates
Chromosome 19: 46,860,997–47,005,077 (GRCh38)
Exons
7 exons across 144.1 kb
Protein
1,499 amino acids
Also known as
GRF-1, p190ARhoGAP, P190A, KIAA1722, p190RhoGAP
Previous symbols
GRLF1
MANE Select transcript
ENST00000672722.1NM_004491.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 1 GenCC submitter rates it definitive or strong

How ARHGAP35 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where ARHGAP35 sits. ARHGAP35 and 23 genes near it on chromosome 19, from 46,433,037 to 47,433,036.Chromosome 1919q13.32p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4346.6 Mb46.8 Mb47 Mb47.2 Mb47.4 MbPNMA8A: 46,466,491–46,471,572, reverse strandPNMA8APNMA8B: 46,486,906–46,495,879, reverse strandPNMA8BCALM3: 46,601,074–46,610,795, forward strandCALM3PTGIR: 46,618,550–46,625,534, reverse strandPTGIRGNG8: 46,633,947–46,639,623, reverse strandGNG8DACT3: 46,646,872–46,661,199, reverse strandDACT3PRKD2: 46,673,661–46,717,144, reverse strandPRKD2STRN4: 46,719,507–46,746,994, reverse strandSTRN4FKRP: 46,746,046–46,776,988, forward strandFKRPSLC1A5: 46,758,394–46,788,617, reverse strandSLC1A5AP2S1: 46,838,136–46,850,962, reverse strandAP2S1ARHGAP35: 46,860,997–47,005,077, forward strandARHGAP35NPAS1: 47,019,474–47,047,242, forward strandNPAS1TMEM160: 47,045,909–47,048,650, reverse strandTMEM160ZC3H4: 47,064,187–47,113,776, reverse strandZC3H4SAE1: 47,113,274–47,210,636, forward strandSAE1BBC3: 47,220,822–47,233,019, reverse strandBBC3CCDC9: 47,255,980–47,274,055, forward strandCCDC9INAFM1: 47,274,373–47,277,755, forward strandINAFM1C5AR1: 47,290,023–47,322,075, forward strandC5AR1C5AR2: 47,332,148–47,347,329, forward strandC5AR2DHX34: 47,349,280–47,383,255, forward strandDHX34MEIS3: 47,403,117–47,419,530, reverse strandMEIS3SLC8A2: 47,428,017–47,472,184, reverse strandSLC8A2Diagram of ARHGAP35: 7 exons on the forward strand of chromosome 19Exon 1: 46,860,997–46,861,209, 213 basesExon 2: 46,918,488–46,922,356, 3,869 basesExon 3: 46,937,264–46,937,408, 145 basesExon 4: 46,987,989–46,988,066, 78 basesExon 5: 46,989,544–46,989,675, 132 basesExon 6: 46,999,304–46,999,409, 106 basesExon 7: 47,000,331–47,005,077, 4,747 bases124675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.3 kb of the gene's 144.1 kb; 4,500 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARHGAP35 gene: Rho GTPase activating protein 35. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgap35

Vancouver

Dante Labs. ARHGAP35 gene: Rho GTPase activating protein 35 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgap35

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