Trait

Parietal cortical atrophy

Atrophy of the parietal cortex.

HPO HP:0012104

Body system: Abnormality of the nervous system

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9 genes linked to Parietal cortical atrophy

Changes in these genes cause rare conditions in which Parietal cortical atrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
MAGEL2MAGE family member L2	Often (30–79%)	In 3 conditions
NDNnecdin, MAGE family member	Often (30–79%)	In 3 conditions
OCA2OCA2 melanosomal transmembrane protein	Often (30–79%)	In 3 conditions
SACSsacsin molecular chaperone	Often (30–79%)	In 1 condition
SCYL2SCY1 like pseudokinase 2	Often (30–79%)	In 1 condition
SNRPNsmall nuclear ribonucleoprotein polypeptide N	Often (30–79%)	In 3 conditions
KDM5Alysine demethylase 5A	Sometimes (5–29%)	In 1 condition
STUB1STIP1 homology and U-box containing protein 1	Sometimes (5–29%)	In 1 condition
TMEM147transmembrane protein 147	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Decrease in size of the outer layer of the brain due to loss of brain cells

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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