Traits

Traits linked to HRAS

HRas proto-oncogene, GTPase

The Human Phenotype Ontology links 206 traits to HRAS, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Adenoma sebaceum	Very often (80–99%)
Big calvaria	Very often (80–99%)
Corners of eye widely separated	Very often (80–99%)
Decreased width of the skull	Very often (80–99%)
Depressed nasal bridge	Very often (80–99%)
Frontal bossing	Very often (80–99%)
Narrow palate	Very often (80–99%)
Prominent back of the head	Very often (80–99%)
Short neck	Very often (80–99%)
Abnormal dentition	Often (30–79%)
Abnormal tooth enamel	Often (30–79%)
Abnormally large tongue	Often (30–79%)
Asymmetry of the posterior head	Often (30–79%)
Eye folds	Often (30–79%)
Facial asymmetry	Often (30–79%)
Full cheeks	Often (30–79%)
Full lower lip	Often (30–79%)
Thickened skin folds of neck	Often (30–79%)
Coarse facial features	Sometimes (5–29%)
Dandy-Walker malformation	Sometimes (5–29%)
Gap between front teeth	Sometimes (5–29%)
Large face	Sometimes (5–29%)
Abnormality of dental color	Not recorded
Abnormality of dental shape	Not recorded
Abnormality of head shape	Not recorded
Anterior position of the premaxilla	Not recorded
Broad forehead	Not recorded
Broad nasal tip	Not recorded
Deep philtrum	Not recorded
Downward slanting of the opening between the eyelids	Not recorded
Drooping lower lip	Not recorded
Fullness around the eyes	Not recorded
High palate	Not recorded
Little lower jaw	Not recorded
Long philtrum	Not recorded
Narrow nasal ridge	Not recorded
Nasal tip, upturned	Not recorded
Open mouth	Not recorded
Pointed chin	Not recorded
Prominent forehead	Not recorded
Redundant neck skin	Not recorded
Round face	Not recorded
Short nose	Not recorded
Webbed neck	Not recorded
Wider-than-typical soft spot of skull	Not recorded

Abnormality of the integument

Trait	How often it is seen
Abnormal fingernails	Very often (80–99%)
Abnormality of the skin	Very often (80–99%)
Afro-textured hair	Very often (80–99%)
Afro-textured scalp hair	Very often (80–99%)
Beauty mark	Very often (80–99%)
Curly hair	Very often (80–99%)
Darkened and thickened skin	Very often (80–99%)
Deep-set nails	Very often (80–99%)
Fine hair	Very often (80–99%)
Hair loss	Very often (80–99%)
Hyperkeratosis	Very often (80–99%)
Linear nevus sebaceous	Very often (80–99%)
Loose redundant skin	Very often (80–99%)
Nevus spilus	Very often (80–99%)
Patchy hypopigmentation of hair	Very often (80–99%)
Spoon-shaped nails	Very often (80–99%)
Tight skin	Very often (80–99%)
Abnormal fingerprints	Often (30–79%)
Congenital posterior occipital alopecia	Often (30–79%)
Irregular hyperpigmentation	Often (30–79%)
Papilloma	Often (30–79%)
Underdeveloped toenails	Often (30–79%)
Verrucous epidermal nevus	Often (30–79%)
Abnormality of the hair	Sometimes (5–29%)
Basal cell carcinoma	Sometimes (5–29%)
Generalized hyperpigmentation	Sometimes (5–29%)
Blue nevus	Rarely (1–4%)
Cutaneous melanoma	Rarely (1–4%)
Excessive sweating	Rarely (1–4%)
Patchy baldness	Rarely (1–4%)
Brittle nails	Not recorded
Giant pigmented mole	Not recorded
Ichthyosis	Not recorded
Mole	Not recorded
Nevus sebaceous	Not recorded
Numerous moles	Not recorded
Patchy darkened skin	Not recorded
Patchy lightened skin	Not recorded
Sparse hair	Not recorded
Thin nail	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Absent/small cerebellum	Very often (80–99%)
Diminished deep tendon reflex	Very often (80–99%)
EEG abnormality	Very often (80–99%)
Epilepsy	Very often (80–99%)
Increased reflexes	Very often (80–99%)
Intellectual disability	Very often (80–99%)
Ventriculomegaly	Very often (80–99%)
Cavity within brain	Often (30–79%)
Decrease in size of the outer layer of the brain due to loss of brain cells	Often (30–79%)
Aplasia/Hypoplasia of the corpus callosum	Sometimes (5–29%)
Neurodevelopmental delay	Sometimes (5–29%)
Fluid-filled sac located in membrane surrounding brain or spinal cord	Rarely (1–4%)
Hyperesthesia	Rarely (1–4%)
Split spine	Rarely (1–4%)
Weakness of one side of body	Rarely (1–4%)
Chiari type I malformation	Not recorded
Degeneration of cerebrum	Not recorded
Enlarged cerebellum	Not recorded
Global developmental delay	Not recorded
Hemimegalencephaly	Not recorded
Obstructive sleep apnea	Not recorded
Too much cerebrospinal fluid in the brain	Not recorded

Abnormality of the eye

Trait	How often it is seen
Abnormally small eyeball	Very often (80–99%)
Cat eye	Very often (80–99%)
Drooping upper eyelid	Very often (80–99%)
Abnormality of the eye	Often (30–79%)
Abnormality of vision	Often (30–79%)
Astigmatism	Often (30–79%)
Bulging cornea	Often (30–79%)
Close sighted	Often (30–79%)
Cross-eyed	Often (30–79%)
Involuntary, rapid, rhythmic eye movements	Often (30–79%)
Optic disc pallor	Often (30–79%)
Compensatory head posture	Sometimes (5–29%)
Corneal opacity	Sometimes (5–29%)
Different colored eyes	Sometimes (5–29%)
Eye muscle paralysis	Sometimes (5–29%)
Farsightedness	Sometimes (5–29%)
Persistent pupillary membrane	Sometimes (5–29%)
Glaucoma	Rarely (1–4%)
Notched pupil	Rarely (1–4%)
Wide-set eyes	Not recorded

Abnormality of limbs

Trait	How often it is seen
Back knee	Very often (80–99%)
Finger bends toward pinky	Often (30–79%)
Thickened Achilles tendon	Often (30–79%)
Asymmetric limb shortening	Sometimes (5–29%)
Short fingers or toes	Sometimes (5–29%)
Asymmetric overgrowth	Rarely (1–4%)
Abnormalities of the fingers	Not recorded
Abnormalities of the toes	Not recorded
Club feet	Not recorded
Deep palm line	Not recorded
Deep wrinkles in soles of feet	Not recorded
Finger joint hyperextensibility	Not recorded
Limited elbow movement	Not recorded
Shortening of the achilles tendon	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Delayed bone maturation	Very often (80–99%)
Low muscle tone	Very often (80–99%)
Vertebral segmentation defect	Very often (80–99%)
Double-Jointed	Often (30–79%)
Scoliosis	Often (30–79%)
Abnormal deposits of calcium in the brain	Sometimes (5–29%)
Hypophosphatemic rickets	Sometimes (5–29%)
Rhabdomyosarcoma	Sometimes (5–29%)
Barrel-shaped chest	Not recorded
Kyphoscoliosis	Not recorded
Osteopenia	Not recorded
Pigeon chest	Not recorded
Recurrent fractures	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Collection of dilated blood vessels that forms mass	Very often (80–99%)
Hole in heart wall separating two lower heart chambers	Very often (80–99%)
Narrowing of pulmonic valve	Very often (80–99%)
Enlarged and thickened heart muscle	Often (30–79%)
Mitral valve prolapse	Often (30–79%)
Abnormal heart rate	Rarely (1–4%)
Raynaud phenomenon	Rarely (1–4%)
Strawberry mark	Rarely (1–4%)
An opening in the wall separating the top two chambers of the heart	Not recorded
Lymphangiectasis	Not recorded
Narrowing of aorta	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Undescended testes	Often (30–79%)
Renal failure	Sometimes (5–29%)
Nephroblastoma	Rarely (1–4%)
Renal transitional cell carcinoma	Rarely (1–4%)
Small kidney on one side	Rarely (1–4%)
Bladder carcinoma	Not recorded
Bladder neoplasm	Not recorded
Horseshoe kidney	Not recorded
Transitional cell carcinoma of the bladder	Not recorded

Growth abnormality

Trait	How often it is seen
Faltering weight in infancy	Very often (80–99%)
Short stature	Very often (80–99%)
Uneven or disproportionate growth of one body part compared to another	Very often (80–99%)
Growth delay	Sometimes (5–29%)
Faltering weight	Not recorded
General overgrowth	Not recorded

Abnormality of the ear

Trait	How often it is seen
Ears rotated toward back of head	Sometimes (5–29%)
Enlarged vestibular aqueduct	Sometimes (5–29%)
Large earlobe	Sometimes (5–29%)
Low-set ears	Not recorded
Vestibular schwannoma	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Early onset of puberty	Sometimes (5–29%)
Pheochromocytoma	Rarely (1–4%)
Follicular thyroid carcinoma	Not recorded
Non-medullary thyroid carcinoma	Not recorded
Papillary thyroid carcinoma	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Bronchomalacia	Not recorded
Collapsed lung	Not recorded
Floppy windpipe	Not recorded
Respiratory failure	Not recorded
Respiratory function loss	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Very often (80–99%)
Acid reflux	Often (30–79%)
Poor suck	Sometimes (5–29%)
Pyloric stenosis	Not recorded

Laboratory abnormality

Trait	How often it is seen
High urine phosphate levels	Sometimes (5–29%)
Swelling caused by excess lymph fluid under skin	Rarely (1–4%)
Low blood sugar	Not recorded

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Often (30–79%)
Premature birth	Not recorded

Abnormality of the voice

Trait	How often it is seen
Hoarse voice	Not recorded

Constitutional symptom

Trait	How often it is seen
Sudden death	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HRAS and how often each is seen. Find out more at hpo.jax.org.

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